CCN6 regulates IGF2BP2 and HMGA2 signaling in metaplastic carcinomas of the breast
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4960-2
Abstract: PurposeMetaplastic breast carcinomas are an aggressive subtype of triple-negative breast cancer (TNBC) in which part or all of the adenocarcinoma transforms into a non-glandular component (e.g., spindled, squamous, or heterologous). We discovered that mammary-specific Ccn6/Wisp3… read more here.
Keywords: breast; ccn6; igf2bp2 hmga2; hmga2 ... See more keywords
The matricellular protein CCN6 differentially regulates mitochondrial metabolism in normal epithelium and in metaplastic breast carcinomas.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cell communication and signaling"
DOI: 10.1007/s12079-021-00657-9
Abstract: Metaplastic breast carcinoma (MBC) is an aggressive subtype of triple negative breast cancer with undefined precursors, limited response to chemotherapy, and frequent distant metastasis. Our laboratory has reported that CCN6/WISP3, a secreted protein that regulates… read more here.
Keywords: mmtv cre; breast; metaplastic breast; ccn6 ... See more keywords
CCN6 improves hepatic steatosis, inflammation, and fibrosis in non‐alcoholic steatohepatitis
Sign Up to like & getrecommendations! Published in 2022 at "Liver International"
DOI: 10.1111/liv.15430
Abstract: CCN6 is a secretory protein with functions of maintaining mitochondrial homeostasis and anti‐oxidative stress; and yet, whether it is involved in the pathogenesis of non‐alcoholic steatohepatitis (NASH) is still obscure. We investigated the role and… read more here.
Keywords: ccn6; non alcoholic; alcoholic steatohepatitis; ccn6 improves ... See more keywords