Primary large B‐cell lymphoma of the central nervous system with cyclin D1 expression and t(11;14) (IGH‐CCND1): Diffuse large B‐cell lymphoma with CCND1 rearrangement or mantle cell lymphoma?
Sign Up to like & getrecommendations! Published in 2020 at "Hematological Oncology"
DOI: 10.1002/hon.2779
Abstract: Mantle cell lymphomas (MCLs) are the prototypic B‐cell non‐Hodgkin lymphomas defined by cyclin D1 gene (CCND1; or other cyclin D family gene) rearrangements. However, extremely rare cases of diffuse large B‐cell lymphomas (DLBCLs) harboring CCND1… read more here.
Keywords: igh ccnd1; large cell; ccnd1; cell ... See more keywords
Changes in the Metastatic Properties of MDA-MB-231 Cells after IGFBP6 Gene Knockdown Is Associated with Increased Expression of miRNA Genes Controlling INSR, IGF1R, and CCND1 Genes
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-019-04409-z
Abstract: Metastatic cascade is associated with the process of epithelial-mesenchymal transition accompanied by changes in cell proliferation, migration, adhesion, and invasiveness mediated by the insulin-like growth factor (IGF) signal pathway. IGFBP6 protein binds IGF and prevents… read more here.
Keywords: igfbp6 gene; mda 231; gene knockdown; insr ... See more keywords
Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1807704115
Abstract: Significance The deubiquitylase USP22 is frequently overexpressed in cancer and contributes to tumorigenesis by driving cell cycle progression. Current models define USP22 as functional mediator of gene regulation and chromatin modification, working within the SAGA… read more here.
Keywords: cancer; progression; ccnd1; cell cycle ... See more keywords
Circ_0030411 aggravates cisplatin-resistance in non-small cell lung cancer by serving as a miR-495-3p sponge to enhance CCND1 expression.
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DOI: 10.1080/1120009x.2022.2162218
Abstract: Circular RNAsplay important modulators in cisplatin (DDP) resistant non-small cell lung cancer (NSCLC). Herein, the role and mechanism of circ_0030411 in DDP-resistant NSCLC was explored. Circ_0030411, miR-495-3p, CCND1, PCNA, Bax, E-cadherin, and ki-67 expression were… read more here.
Keywords: cell; circ 0030411; ccnd1; ddp resistant ... See more keywords
Cyclin D1 mediated by the nuclear translocation of nuclear factor kappa B exerts an oncogenic role in lung cancer
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2043099
Abstract: ABSTRACT The relevance of cyclin D1 (CCND1) has been implicated in lung cancer progression. Nevertheless, the mechanism by which CCND1 supports lung cancer development is yet to be expounded. Here, we established that CCND1 is… read more here.
Keywords: lung; nuclear translocation; ccnd1; lung cancer ... See more keywords
Resveratrol Suppresses Growth and Migration of Myelodysplastic Cells by Inhibiting the Expression of Elevated Cyclin D1 (CCND1).
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3846
Abstract: Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases characterized by poorly formed blood cells. We wanted to elucidate the underlying molecular mechanism to better determine pathogenesis, prognosis, diagnosis, and treatment for patients with MDS.… read more here.
Keywords: resveratrol; migration; expression; ccnd1 ... See more keywords
Intratumor heterogeneity predicts metastasis of triple-negative breast cancer
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DOI: 10.1093/carcin/bgx071
Abstract: Even with the identical clinicopathological features, the ability for metastasis is vastly different among triple-negative breast cancer (TNBC) patients. Intratumor heterogeneity (ITH), which is common in breast cancer, may be a key mechanism leading to… read more here.
Keywords: metastasis; heterogeneity; ccnd1; breast cancer ... See more keywords
High-resolution simulations of chromatin folding at genomic rearrangements in malignant B cells provide mechanistic insights into proto-oncogene deregulation
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DOI: 10.1101/gr.276028.121
Abstract: Genomic rearrangements are known to result in proto-oncogene deregulation in many cancers, but the link to genome 3D structure remains poorly understood. Here we used the highly-predictive heteromorphic polymer (HiP-HoP) model to predict chromatin conformations… read more here.
Keywords: ccnd1; proto oncogene; genomic rearrangements; oncogene deregulation ... See more keywords
Quadruple‐hit pleomorphic mantle cell lymphoma with MYC, BCL2, BCL6, and CCND1 gene rearrangements
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DOI: 10.1111/bjh.17729
Abstract: B-cell lymphomas that concurrently carry MYC, BCL2 and/ or BCL6 gene rearrangements – so-called double-hit or triple-hit lymphomas – are rare entities associated with poor prognosis. B-cell lymphomas with translocations involving MYC, BCL2, BCL6 and… read more here.
Keywords: bcl6; ccnd1; bcl2; gene ... See more keywords
Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/4370873
Abstract: Background Osteoarthritis (OA) serves as one of the most prevalent types of joint disorders and is a leading cause of symptoms of stiffness, swelling, and arthralgia. Circular RNAs (circRNAs) have been reported to participate in… read more here.
Keywords: proliferation; ccnd1; circrhot1; circular rna ... See more keywords
Abstract PD4-07: Genenomic landscape of breast cancers with FGFR1 amplification and FGFR1/CCND1 co-amplification revealed by targeted capture next generation sequencing
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs17-pd4-07
Abstract: Background: FGFR1 amplification (amp) occurs in ˜15% of breast cancers (BC) and associates with poor prognosis and resistance to endocrine therapy. CCND1 regulates cell cycle progression and is amplified in 15-20% of BC. Co-amp of… read more here.
Keywords: breast; fgfr1 amplification; fgfr1; fgfr1 ccnd1 ... See more keywords