Functional variant rs9344 at 11q13.3 regulates CCND1 expression in multiple myeloma with t(11;14)
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DOI: 10.1038/s41375-024-02363-y
Abstract: Multiple myeloma (MM) is a plasma cell (PC) malignancy characterized by cytogenetic abnormalities, such as t(11;14)(q13;q32), resulting in CCND1 overexpression. The rs9344 G allele within CCND1 is the most significant susceptibility allele for t(11;14). Sequencing… read more here.
Keywords: multiple myeloma; variant rs9344; ccnd1 expression; functional variant ... See more keywords
pncCCND1_B Engages an Inhibitory Protein Network to Downregulate CCND1 Expression upon DNA Damage
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DOI: 10.3390/cancers14061537
Abstract: Simple Summary Ewing sarcoma is a pediatric tumor characterized by chromosomal translocations, giving rise to the oncogene EWS-FLI1, which triggers the transcription of genes involved in neoplastic transformation including CCND1. In this work, we found… read more here.
Keywords: promoter; ccnd1; rna; ccnd1 expression ... See more keywords