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   Articles with "ccr2" as a keyword



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Heteromerization between α1B‐adrenoceptor and chemokine (C‐C motif) receptor 2 biases α1B‐adrenoceptor signaling: Implications for vascular function

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14463

Abstract: Previously, we reported that chemokine (C‐C motif) receptor 2 (CCR2) heteromerizes with α1B‐adrenoceptor (α1B‐AR) in leukocytes, through which α1B‐AR controls CCR2. Whether such heteromers are expressed in human vascular smooth muscle cells (hVSMCs) is unknown.… read more here.

Keywords: adrenoceptor; ccr2; chemokine motif; motif receptor ... See more keywords
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PCSK9 regulates the chemokine receptor CCR2 on monocytes.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.02.085

Abstract: Monocyte migration is a key element in atherosclerosis. LDL-C facilitates monocyte migration via induction of CCR2. PCSK9 regulates cell surface expression of the LDL-R and is expressed in vascular smooth muscle cells (VSMCs). The present… read more here.

Keywords: pcsk9 regulates; ccr2; ldl; expression ... See more keywords
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Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.11.010

Abstract: ABSTRACT Accumulation of alpha‐synuclein (&agr;‐syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and… read more here.

Keywords: agr syn; ccr2; neurodegeneration; parkinson disease ... See more keywords
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Using chemokine sorting to imrpove NK cell function in an anti-tumour model

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.03.341

Abstract: Background & Aim The immune system plays an important role in checking the development of tumours. While many inroads have been made into the role various immune cell types play within the context of cancer,… read more here.

Keywords: cancer; anti tumour; ccr2; chemokine ... See more keywords
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Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.

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recommendations! Published in 2017 at "Kidney international"

DOI: 10.1016/j.kint.2016.09.042

Abstract: Inflammation is a central pathophysiologic mechanism that contributes to diabetes mellitus and diabetic nephropathy. Recently, we showed that macrophages directly contribute to diabetic renal injury and that pharmacological blockade or genetic deficiency of chemokine (C-C… read more here.

Keywords: chemokine motif; ccr2; renal injury; diabetic nephropathy ... See more keywords
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Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118808

Abstract: BACKGROUND/AIMS The theory of inflammation is one of the important theories in the pathogenesis of diabetic nephropathy (DN). We herein aimed to explore whether loganin affected macrophage infiltration and activation upon diabetic nephropathy (DN) by… read more here.

Keywords: loganin; ccr2; infiltration activation; macrophage infiltration ... See more keywords
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Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00263

Abstract: Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays. Here, we report the structure-based… read more here.

Keywords: fluorescent ligands; ccr2; allosteric binding; targeting intracellular ... See more keywords
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A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-00104-z

Abstract: CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical efficacy… read more here.

Keywords: high receptor; ccr2; receptor occupancy; novel ccr2 ... See more keywords
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Calming egress of inflammatory monocytes and related septic shock by therapeutic CCR2 silencing using macrophage-derived extracellular vesicles.

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recommendations! Published in 2022 at "Nanoscale"

DOI: 10.1039/d1nr06922e

Abstract: Uncontrolled inflammation, featuring the aggravated mobilization of Ly6Chigh inflammatory monocytes (Mos), may cause high morbidity and mortality in the pathogenesis of sepsis-associated immune disorders. Inspired by the similar membrane protein profile of extracellular vehicles (EVs)… read more here.

Keywords: inflammatory monocytes; ccr2; inflammatory; egress inflammatory ... See more keywords
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Recruitment of CCR2+ tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

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recommendations! Published in 2018 at "OncoImmunology"

DOI: 10.1080/2162402x.2018.1470729

Abstract: ABSTRACT The tumor microenvironment (TME) represents a significant barrier to creating effective therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow derived CCR2+ inflammatory monocytes (IM) are recruited to the TME by neoplastic… read more here.

Keywords: mcrc; tumor associated; ccr2; colorectal cancer ... See more keywords
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Targeting the CCL2-CCR2 axis for atheroprotection.

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recommendations! Published in 2022 at "European heart journal"

DOI: 10.1093/eurheartj/ehac094

Abstract: Decades of research have established atherosclerosis as an inflammatory disease. Only recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-inflammatory strategies with respect to cardiovascular events, thus offering a new paradigm for… read more here.

Keywords: targeting ccl2; axis atheroprotection; ccr2; ccl2 ccr2 ... See more keywords