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   Articles with "ccr2" as a keyword



Heteromerization between α1B‐adrenoceptor and chemokine (C‐C motif) receptor 2 biases α1B‐adrenoceptor signaling: Implications for vascular function

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14463

Abstract: Previously, we reported that chemokine (C‐C motif) receptor 2 (CCR2) heteromerizes with α1B‐adrenoceptor (α1B‐AR) in leukocytes, through which α1B‐AR controls CCR2. Whether such heteromers are expressed in human vascular smooth muscle cells (hVSMCs) is unknown.… read more here.

Keywords: adrenoceptor; ccr2; chemokine motif; motif receptor ... See more keywords

CCR2-Engineered Macrophage Membrane-Coated Metal-Polyphenol Nanozyme to Enhance Antioxidation Activity for Inhibiting the Atherosclerotic Progression.

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recommendations! Published in 2025 at "Advanced healthcare materials"

DOI: 10.1002/adhm.202502151

Abstract: Atherosclerosis (AS) is a prevalent chronic inflammatory disease characterized by excessive accumulation of reactive oxygen species (ROS) and persistent inflammation. Polyphenolic natural antioxidants possess strong ROS‐scavenging properties. However, the poor targeting ability and rapid metabolism… read more here.

Keywords: ccr2 engineered; progression; ccr2; macrophage ... See more keywords

PCSK9 regulates the chemokine receptor CCR2 on monocytes.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.02.085

Abstract: Monocyte migration is a key element in atherosclerosis. LDL-C facilitates monocyte migration via induction of CCR2. PCSK9 regulates cell surface expression of the LDL-R and is expressed in vascular smooth muscle cells (VSMCs). The present… read more here.

Keywords: pcsk9 regulates; ccr2; ldl; expression ... See more keywords

Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

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recommendations! Published in 2018 at "Experimental Neurology"

DOI: 10.1016/j.expneurol.2017.11.010

Abstract: ABSTRACT Accumulation of alpha‐synuclein (&agr;‐syn) in the central nervous system (CNS) is a core feature of Parkinson disease (PD) that leads to activation of the innate immune system, production of inflammatory cytokines and chemokines, and… read more here.

Keywords: agr syn; ccr2; neurodegeneration; parkinson disease ... See more keywords

Using chemokine sorting to imrpove NK cell function in an anti-tumour model

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recommendations! Published in 2019 at "Cytotherapy"

DOI: 10.1016/j.jcyt.2019.03.341

Abstract: Background & Aim The immune system plays an important role in checking the development of tumours. While many inroads have been made into the role various immune cell types play within the context of cancer,… read more here.

Keywords: cancer; anti tumour; ccr2; chemokine ... See more keywords

Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.

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recommendations! Published in 2017 at "Kidney international"

DOI: 10.1016/j.kint.2016.09.042

Abstract: Inflammation is a central pathophysiologic mechanism that contributes to diabetes mellitus and diabetic nephropathy. Recently, we showed that macrophages directly contribute to diabetic renal injury and that pharmacological blockade or genetic deficiency of chemokine (C-C… read more here.

Keywords: chemokine motif; ccr2; renal injury; diabetic nephropathy ... See more keywords

Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy.

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recommendations! Published in 2020 at "Life sciences"

DOI: 10.1016/j.lfs.2020.118808

Abstract: BACKGROUND/AIMS The theory of inflammation is one of the important theories in the pathogenesis of diabetic nephropathy (DN). We herein aimed to explore whether loganin affected macrophage infiltration and activation upon diabetic nephropathy (DN) by… read more here.

Keywords: loganin; ccr2; infiltration activation; macrophage infiltration ... See more keywords

Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2.

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recommendations! Published in 2022 at "ACS chemical biology"

DOI: 10.1021/acschembio.2c00263

Abstract: Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range of different applications, including bioluminescence resonance energy transfer (BRET) assays. Here, we report the structure-based… read more here.

Keywords: fluorescent ligands; ccr2; allosteric binding; targeting intracellular ... See more keywords

A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-00104-z

Abstract: CC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical efficacy… read more here.

Keywords: high receptor; ccr2; receptor occupancy; novel ccr2 ... See more keywords

CCR2+ monocytes/macrophages drive steroid hormone imbalance-related prostatic fibrosis

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-65574-4

Abstract: Benign Prostatic Hyperplasia (BPH) is a complex condition leading to Lower Urinary Tract Symptoms in aging men, characterized by cellular proliferation, smooth muscle dysfunction, inflammation, and fibrosis. While BPH is known to involve heightened macrophage… read more here.

Keywords: mice; monocytes macrophages; fibrosis; ccr2 ... See more keywords

Pharmacological inhibition of the CCL2-CCR2 axis fails to reduce inflammation in a rat model of acute lung injury

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-11971-2

Abstract: New therapeutic approaches are needed to regulate inflammation and control monocyte recruitment in acute respiratory distress syndrome (ARDS). Excessive monocyte influx into the alveolar space can exacerbate lung damage, worsening patient outcomes. Delaying or reducing… read more here.

Keywords: ccr2; ccl2 ccr2; lung injury; inflammation ... See more keywords