Synthesis and Pharmacological Evaluation of Triazolopyrimidinone Derivatives as Noncompetitive, Intracellular Antagonists for CC Chemokine Receptors 2 and 5
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00742
Abstract: CC chemokine receptors 2 (CCR2) and 5 (CCR5) are involved in many inflammatory diseases; however, most CCR2 and CCR5 clinical candidates have been unsuccessful. (Pre)clinical evidence suggests that dual CCR2/CCR5 inhibition might be more effective… read more here.
Keywords: triazolopyrimidinone derivatives; pharmacological evaluation; synthesis pharmacological; chemokine receptors ... See more keywords
THU0039 DECIPHERING DISEASE-RELEVANT T CELL SUBSETS IN RHEUMATOID ARTHRITIS IDENTIFIES A NOVEL CELLULAR SUBSET OF PATHOGENETIC IMPORTANCE IN THERAPEUTIC RESISTANCE.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.5525
Abstract: Background: Aberrant T cell responses are key in driving autoimmunity and are commonly associated with rheumatoid arthritis (RA). Unravelling pathways of importance in therapeutic partial response and failure is of critical importance, as this will… read more here.
Keywords: arthritis; ccr2 ccr5; cell; disease ... See more keywords
CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2019 at "European Respiratory Journal"
DOI: 10.1183/13993003.02308-2018
Abstract: Macrophages are major players in the pathogenesis of pulmonary arterial hypertension (PAH). To investigate whether lung macrophages and pulmonary-artery smooth muscle cells (PASMCs) collaborate to stimulate PASMC growth and whether the CCL2-CCR2 and CCL5-CCR5 pathways… read more here.
Keywords: smooth muscle; macrophage; pasmc; ccr5 ... See more keywords
Evolution of CCR5 and CCR2 Genes in Bats Showed Multiple Independent Gene Conversion Events
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020169
Abstract: Chemokine receptors are an important determinant for the infectiousness of different pathogens, which are able to target the host cells by binding to the extracellular domains of these proteins. This is the mechanism of infection… read more here.
Keywords: ccr2; ccr5; ccr2 ccr5; gene conversion ... See more keywords