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   Articles with "ccr4" as a keyword



Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates

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recommendations! Published in 2018 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12331

Abstract: Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion. We have demonstrated that… read more here.

Keywords: depletion; ccr4; ccr4 immunotoxin; ccr4 treg ... See more keywords

CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model.

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recommendations! Published in 2023 at "FEBS open bio"

DOI: 10.1002/2211-5463.13625

Abstract: Cutaneous T-cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30% and none of these treatments are… read more here.

Keywords: ctcl; ccr4 il2; mouse; model ... See more keywords

CCR4+CD8+ T cells clonally expand to differentiated effectors in murine psoriasis and in human psoriatic arthritis

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recommendations! Published in 2023 at "European Journal of Immunology"

DOI: 10.1002/eji.202149702

Abstract: Psoriasis is a chronic inflammatory skin disease with an autoimmune component and associated with joint inflammation in up to 30% of cases. To investigate autoreactive T cells, we developed an imiquimod‐induced psoriasis‐like inflammation model in… read more here.

Keywords: psoriasis; psoriatic arthritis; cd8 cells; ccr4 ... See more keywords

Enhancing hepatocellular carcinoma management: prognostic value of integrated CCL17, CCR4, CD73, and HHLA2 expression analysis

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recommendations! Published in 2024 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-024-05832-0

Abstract: Hepatocellular carcinoma (HCC) is a critical global health concern, with existing treatments benefiting only a minority of patients. Recent findings implicate the chemokine ligand 17 (CCL17) and its receptor CCR4 as pivotal players in the… read more here.

Keywords: ccr4; ccr4 cd73; hcc; ccl17 ccr4 ... See more keywords

CCR4+ monocytic myeloid-derived suppressor cells are associated with the increased epithelial-mesenchymal transition in pancreatic adenocarcinoma patients.

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recommendations! Published in 2022 at "Immunobiology"

DOI: 10.1016/j.imbio.2022.152210

Abstract: Among all the cancer-related deaths globally, pancreatic ductal adenocarcinoma (PDAC) accounts for the seventh leading cause of mortality. A dysregulated immune system disrupts anti-tumor immunity by abnormal accumulation of myeloid-derived suppressor cells (MDSCs), but the… read more here.

Keywords: tumor; mesenchymal transition; mdscs; ccr4 ... See more keywords

Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.

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recommendations! Published in 2019 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.9b00506

Abstract: Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human Treg express CCR4 and… read more here.

Keywords: ccr4; tumor microenvironment; discovery potent; tumor ... See more keywords

Ischemic stroke outcome after promoting CD4+CD25+ Treg cell migration through CCR4 overexpression in a tMCAO animal model

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recommendations! Published in 2024 at "Scientific Reports"

DOI: 10.1038/s41598-024-60358-2

Abstract: The importance of neuroinflammation during the ischemic stroke has been extensively studied. The role of CD4+CD25+ regulatory T (Treg) cells during the recovery phase have shown infarct size reduction and functional improvement, possibly through the… read more here.

Keywords: ccr4; migration; treg cells; cell ... See more keywords

Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2118238119

Abstract: Significance Interactions between the nervous and immune systems control the generation and maintenance of inflammatory pain. However, the immune cells and mediators controlling this response remain poorly characterized. We identified the cytokines CCL22 and CCL17… read more here.

Keywords: skin resident; resident dendritic; postoperative pain; pain ... See more keywords

CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis.

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recommendations! Published in 2022 at "International immunology"

DOI: 10.1093/intimm/dxac041

Abstract: Th17 cells express CCR4 and secrete cytokines such as IL-17A and GM-CSF, while dendritic cells (DCs) produce CCL22, a CCR4 ligand, upon stimulation with GM-CSF. Th17 cells are known to play a critical role in… read more here.

Keywords: th17 cells; role; arthritis; th17 ... See more keywords

RNA binding proteins Smaug and Cup induce CCR4–NOT-dependent deadenylation of the nanos mRNA in a reconstituted system

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkad159

Abstract: Posttranscriptional regulation of the maternal nanos mRNA is essential for the development of the anterior – posterior axis of the Drosophila embryo. The nanos RNA is regulated by the protein Smaug. Binding to Smaug recognition… read more here.

Keywords: cup; dependent deadenylation; deadenylation; smaug dependent ... See more keywords

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity

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recommendations! Published in 2019 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkz509

Abstract: Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and… read more here.

Keywords: ccr4 complex; ccr4; inhibits cnot7; dead box ... See more keywords