Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12331
Abstract: Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion. We have demonstrated that… read more here.
Keywords: depletion; ccr4; ccr4 immunotoxin; ccr4 treg ... See more keywords
CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model.
Sign Up to like & getrecommendations! Published in 2023 at "FEBS open bio"
DOI: 10.1002/2211-5463.13625
Abstract: Cutaneous T-cell lymphoma (CTCL) encompasses two main subtypes: mycosis fungoides and Sezary syndrome. Global response rates for the systemic treatment of mycosis fungoides and Sezary syndrome are approximately 30% and none of these treatments are… read more here.
Keywords: ctcl; ccr4 il2; mouse; model ... See more keywords
CCR4+CD8+ T cells clonally expand to differentiated effectors in murine psoriasis and in human psoriatic arthritis
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202149702
Abstract: Psoriasis is a chronic inflammatory skin disease with an autoimmune component and associated with joint inflammation in up to 30% of cases. To investigate autoreactive T cells, we developed an imiquimod‐induced psoriasis‐like inflammation model in… read more here.
Keywords: psoriasis; psoriatic arthritis; cd8 cells; ccr4 ... See more keywords
CCR4+ monocytic myeloid-derived suppressor cells are associated with the increased epithelial-mesenchymal transition in pancreatic adenocarcinoma patients.
Sign Up to like & getrecommendations! Published in 2022 at "Immunobiology"
DOI: 10.1016/j.imbio.2022.152210
Abstract: Among all the cancer-related deaths globally, pancreatic ductal adenocarcinoma (PDAC) accounts for the seventh leading cause of mortality. A dysregulated immune system disrupts anti-tumor immunity by abnormal accumulation of myeloid-derived suppressor cells (MDSCs), but the… read more here.
Keywords: tumor; mesenchymal transition; mdscs; ccr4 ... See more keywords
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00506
Abstract: Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor response in patients receiving treatment with immuno-oncology (IO) agents. Human Treg express CCR4 and… read more here.
Keywords: ccr4; tumor microenvironment; discovery potent; tumor ... See more keywords
Skin-resident dendritic cells mediate postoperative pain via CCR4 on sensory neurons
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2118238119
Abstract: Significance Interactions between the nervous and immune systems control the generation and maintenance of inflammatory pain. However, the immune cells and mediators controlling this response remain poorly characterized. We identified the cytokines CCL22 and CCL17… read more here.
Keywords: skin resident; resident dendritic; postoperative pain; pain ... See more keywords
CCR4 plays a pivotal role in Th17 cell recruitment and expansion in a mouse model of rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac041
Abstract: Th17 cells express CCR4 and secrete cytokines such as IL-17A and GM-CSF, while dendritic cells (DCs) produce CCL22, a CCR4 ligand, upon stimulation with GM-CSF. Th17 cells are known to play a critical role in… read more here.
Keywords: th17 cells; role; arthritis; th17 ... See more keywords
RNA binding proteins Smaug and Cup induce CCR4–NOT-dependent deadenylation of the nanos mRNA in a reconstituted system
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad159
Abstract: Posttranscriptional regulation of the maternal nanos mRNA is essential for the development of the anterior – posterior axis of the Drosophila embryo. The nanos RNA is regulated by the protein Smaug. Binding to Smaug recognition… read more here.
Keywords: cup; dependent deadenylation; deadenylation; smaug dependent ... See more keywords
DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz509
Abstract: Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and… read more here.
Keywords: ccr4 complex; ccr4; inhibits cnot7; dead box ... See more keywords
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aan3638
Abstract: Destabilization of Atg7 mRNA by the CCR4-NOT complex prevents p53-dependent cell death in the heart. Protecting the heart by destabilizing mRNA The removal of polyadenylate tails from mRNAs by the CCR4-NOT complex marks these mRNAs… read more here.
Keywords: death; heart; death heart; ccr4 ... See more keywords
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Investigation"
DOI: 10.1172/jci82976
Abstract: Elevated expression of the chemokine receptor CCR4 in tumors is associated with poor prognosis in several cancers. Here, we have determined that CCR4 was highly expressed in human renal cell carcinoma (RCC) biopsies and observed… read more here.
Keywords: ccr4 antagonist; ccr4; antibody; anti ccr4 ... See more keywords