PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.05.009
Abstract: Multiple deadenylases are known in vertebrates, the PAN2-PAN3 (PAN2/3) and CCR4-NOT (CNOT) complexes, and PARN, yet their differential functions remain ambiguous. Moreover, the role of poly(A) binding protein (PABP) is obscure, limiting our understanding of the… read more here.
Keywords: decay; ccr4 complex; mrna deadenylation; pabp cooperates ... See more keywords
Essential functions of the CNOT7/8 catalytic subunits of the CCR4-NOT complex in mRNA regulation and cell viability
Sign Up to like & getrecommendations! Published in 2020 at "RNA Biology"
DOI: 10.1080/15476286.2019.1709747
Abstract: ABSTRACT Shortening of mRNA poly(A) tails (deadenylation) to trigger their decay is mediated mainly by the CCR4-NOT deadenylase complex. While four catalytic subunits (CNOT6, 6L 7, and 8) have been identified in the mammalian CCR4-NOT… read more here.
Keywords: ccr4 complex; dko mefs; viability; catalytic subunits ... See more keywords
Bidirectional roles of the Ccr4-Not complex in regulating autophagy before and after nitrogen starvation
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2036476
Abstract: ABSTRACT Macroautophagy/autophagy is a highly conserved catabolic process by which cytoplasmic constituents are delivered to the vacuole/lysosome for degradation and recycling. To maintain cellular homeostasis and prevent pathologies, the induction and amplitude of autophagy activity… read more here.
Keywords: atg; regulating autophagy; starvation; ccr4 complex ... See more keywords
DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz509
Abstract: Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and… read more here.
Keywords: ccr4 complex; ccr4; inhibits cnot7; dead box ... See more keywords
The CCR4-NOT Complex Maintains Stability and Transcription of rRNA Genes by Repressing Antisense Transcripts
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00320-19
Abstract: The rRNA genes (rDNA) in eukaryotes are organized into highly repetitive gene clusters. Each organism maintains a particular number of copies, suggesting that the rDNA is actively stabilized. We previously identified about 700 Saccharomyces cerevisiae… read more here.
Keywords: rrna genes; unstable rdna; rdna; pop2 ... See more keywords
Drosophila Bag-of-marbles directly interacts with the CAF40 subunit of the CCR4-NOT complex to elicit repression of mRNA targets.
Sign Up to like & getrecommendations! Published in 2018 at "RNA"
DOI: 10.1261/rna.064584.117
Abstract: Drosophila melanogaster Bag-of-marbles (Bam) promotes germline stem cell (GSC) differentiation by repressing the expression of mRNAs encoding stem cell maintenance factors. Bam interacts with Benign gonial cell neoplasm (Bgcn) and the CCR4 deadenylase, a catalytic… read more here.
Keywords: ccr4 complex; ccr4; subunit ccr4; bag marbles ... See more keywords
Regulation of eukaryotic mRNA deadenylation and degradation by the Ccr4-Not complex
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1153624
Abstract: Accurate and precise regulation of gene expression programmes in eukaryotes involves the coordinated control of transcription, mRNA stability and translation. In recent years, significant progress has been made about the role of sequence elements in… read more here.
Keywords: mrna; deadenylation; regulation; ccr4 complex ... See more keywords
Regulation of Early Lymphocyte Development via mRNA Decay Catalyzed by the CCR4-NOT Complex
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.715675
Abstract: Development of lymphocytes is precisely regulated by various mechanisms. In addition to transcriptional rates, post-transcriptional regulation of mRNA abundance contributes to differentiation of lymphocytes. mRNA decay is a post-transcriptional mechanism controlling mRNA abundance. The carbon… read more here.
Keywords: ccr4; lymphocyte development; mrna decay; ccr4 complex ... See more keywords