Dosing optimization of CCR4 immunotoxin for improved depletion of CCR4+ Treg in nonhuman primates
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DOI: 10.1002/1878-0261.12331
Abstract: Recently, we have developed a diphtheria toxin‐based recombinant anti‐human CCR4 immunotoxin for targeting CCR4+ tumors and Tregs. In this study, we further optimized the dosing schedule for improved CCR4+ Treg depletion. We have demonstrated that… read more here.
Keywords: depletion; ccr4; ccr4 immunotoxin; ccr4 treg ... See more keywords