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   Articles with "ccr5" as a keyword



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Implication of HMOX1 and CCR5 genotypes on clinical phenotype of Egyptian patients with sickle cell anemia

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recommendations! Published in 2019 at "Annals of Hematology"

DOI: 10.1007/s00277-019-03697-9

Abstract: Sickle cell disease (SCD) is a relatively common inherited hemolytic anemia among individuals of African descent. Genetic factors might clarify clinical diversity of the disease and variations in treatment response. Some researchers investigated heme oxygenase-1… read more here.

Keywords: ccr5 genotypes; disease; ccr5; sickle cell ... See more keywords
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Association analysis and allelic distribution of deletion in CC chemokine receptor 5 gene (CCR5Δ32) among breast cancer patients of Pakistan

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recommendations! Published in 2019 at "Molecular Biology Reports"

DOI: 10.1007/s11033-019-04699-6

Abstract: Chemokine CC receptor type 5 (CCR5) is a cell surface receptor that has high affinity for chemotropic cytokines called chemokines. The CCR5 gene contains a 32 base pairs (bp) deletion (CCR5Δ32). This deletion may result… read more here.

Keywords: breast cancer; deletion; cancer; ccr5 ... See more keywords
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CCR5-Δ32 gene variant frequency in the Turkish Cypriot population

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recommendations! Published in 2020 at "Brazilian Journal of Microbiology"

DOI: 10.1007/s42770-020-00352-8

Abstract: Recent UNAIDS reports (December 2019) indicate that 37.9 million people have been affected by HIV infection around the globe in 2018, of which 1.7 million are cited as new infections. Human immunodeficiency virus-1 (HIV-1) requires… read more here.

Keywords: frequency; turkish cypriot; ccr5 gene; cypriot population ... See more keywords
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The G protein coupled receptor CCR5 in cancer.

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recommendations! Published in 2020 at "Advances in cancer research"

DOI: 10.1016/bs.acr.2019.11.001

Abstract: The G coupled protein receptor CC chemokine receptor type 5 (CCR5) has the unusual characteristic in humans of being a developmentally non-essential gene that participates in several pathological processes including infection with HIV (Dean et… read more here.

Keywords: protein; jiao; ccr5 cancer; cancer ... See more keywords
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CCR5 attenuates neutrophilic airway inflammation exacerbated by infection with rhinovirus.

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recommendations! Published in 2020 at "Cellular immunology"

DOI: 10.1016/j.cellimm.2020.104066

Abstract: Human rhinovirus (hRV) is the most common cause of asthma exacerbation characterized by clinical and pathophysiological heterogeneity. Steroid-sensitive, Th2 type-eosinophilic asthma has been somewhat studied, but hRV-induced neutrophilic asthma exacerbation is poorly understood. Here, CCR5… read more here.

Keywords: airway inflammation; asthma exacerbation; mice; ccr5 ... See more keywords
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CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

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recommendations! Published in 2020 at "International Journal of Infectious Diseases"

DOI: 10.1016/j.ijid.2020.10.101

Abstract: Objective Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now a global pandemic. Emerging results indicate a dysregulated immune response. Given the role of CCR5 in immune cell migration and inflammation, we investigated… read more here.

Keywords: covid patients; sars cov2; ccr5; critical covid ... See more keywords
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CCR5Δ32 mutations do not determine COVID-19 disease course

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recommendations! Published in 2021 at "International Journal of Infectious Diseases"

DOI: 10.1016/j.ijid.2021.02.108

Abstract: Objectives To determine the impact of the 32bp deletion (CCR5Δ32) in the coding region of the C-C chemokine receptor 5 (CCR5) on the risk of contracting SARS-CoV-2 and severe COVID-19. Methods Cross-sectional study among stem… read more here.

Keywords: disease course; sars cov; ccr5 mutations; ccr5 ... See more keywords
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A novel dual-luciferase assay for anti-HIV drug screening based on the CCR5/CXCR4 promoters.

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recommendations! Published in 2018 at "Journal of virological methods"

DOI: 10.1016/j.jviromet.2018.02.016

Abstract: Acquired immunodeficiency syndrome (AIDS) is a serious worldwide disease caused by infection with the human immunodeficiency virus (HIV). C-C chemokine receptor 5 (CCR5) and C-X-C chemokine receptor 4 (CXCR4) are important coreceptors mediating HIV-1 cell… read more here.

Keywords: ccr5 cxcr4; cxcr4; anti hiv; ccr5 ... See more keywords
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Infectivity and growth kinetics of Herpes Simplex Virus type-2 in MOLT4 CCR5+ and CEM CCR5+ T cell lines.

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recommendations! Published in 2018 at "Microbial pathogenesis"

DOI: 10.1016/j.micpath.2018.06.035

Abstract: Herpes simplex virus type-2 (HSV-2) is an important sexually transmitted pathogen that infects the genital mucosal epithelial cells causing ulcerative lesions at the site of entry, facilitating HIV infection. The infection of epithelial cells and… read more here.

Keywords: hsv; cem ccr5; cell lines; molt4 ccr5 ... See more keywords
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CCR5/CCR5 ligand-induced myeloid-derived suppressor cells are related to the progression of endometriosis.

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recommendations! Published in 2019 at "Reproductive biomedicine online"

DOI: 10.1016/j.rbmo.2019.05.014

Abstract: RESEARCH QUESTION Immunological disorders have been reported to promote the progression of endometriosis. Several recent studies have shown that myeloid-derived suppressor cells (MDSC) drive the progression of endometriosis. The aim of this case-control study was… read more here.

Keywords: ccr5 mdsc; ccr5; progression endometriosis; endometriosis ... See more keywords
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Generation of human induced pluripotent stem cells from individuals with a homozygous CCR5Δ32 mutation

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recommendations! Published in 2019 at "Stem cell research"

DOI: 10.1016/j.scr.2019.101481

Abstract: Chemokine receptor 5 (CCR5) is the primary coreceptor for HIV entry into macrophages. Individuals with a homozygous deletion of 32 bp in the CCR5 gene (CCR5Δ32) are highly resistant to HIV infection (Samson et al.,… read more here.

Keywords: individuals homozygous; homozygous ccr5; pluripotent stem; induced pluripotent ... See more keywords