Activation of CCL20 and its receptor CCR6 promotes endometrium preparation for implantation and placenta development during the early pregnancy period in pigs
Sign Up to like & getrecommendations! Published in 2019 at "Developmental and Comparative Immunology"
DOI: 10.1016/j.dci.2018.11.005
Abstract: ABSTRACT The success of implantation and placentation during early pregnancy depends on the intrauterine environment of diverse histotrophs, including nutrients, growth factors, cytokines, and chemokines. Here, we determined the functional role and signal transduction of… read more here.
Keywords: ccl20 receptor; pregnancy; ccl20; ccr6 ... See more keywords
CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.10.013
Abstract: CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling… read more here.
Keywords: induced treg; gut inflammation; ccr6; ccr6 signaling ... See more keywords
Association study of CCR6 rs3093024 with Rheumatoid Arthritis in a Pakistani cohort
Sign Up to like & getrecommendations! Published in 2020 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2020.08.045
Abstract: C-C Chemokine receptor 6 (CCR6), an important protein in inflammatory and immunological responses, has been previously reported to be associated with rheumatoid arthritis (RA). Therefore, in order to replicate these findings, a case-control study was… read more here.
Keywords: ccr6 rs3093024; ccr6; study; rs3093024 variant ... See more keywords
CCL20, a direct‐acting pro‐angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV‐related liver cancer
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.09.023
Abstract: Abstract The CCL20/CCR6 chemokine/receptor axis has previously been shown to contribute to the initiation and progression of hepatocellular carcinoma (HCC) through the recruitment of CCR6‐positive leukocytes to the tumor microenvironment. In particular, high serum levels… read more here.
Keywords: pro angiogenic; hcc; ccl20; ccl20 direct ... See more keywords
Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16820-6
Abstract: Chemokines are important protein-signaling molecules that regulate various immune responses by activating chemokine receptors which belong to the G protein-coupled receptor (GPCR) superfamily. Despite the substantial progression of our structural understanding of GPCR activation by… read more here.
Keywords: protein; ccr6; activation; chemokine receptor ... See more keywords
Abstract 4779: Targeting the CCL20-CCR6 axis as a novel opportunity to stimulataneously modulate cancer stem cells and the tumor-immune infiltrate by a dual anti-cancer mechanism
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4779
Abstract: Drugs that target cancer stem cells (CSCs) are thought to be a critical component of any successful therapy against cancer. CSCs are responsible for chemoresistance, metastasis, and ultimately relapse of the cancer, even after an… read more here.
Keywords: ccl20; ccr6; cancer; stem cells ... See more keywords
Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202115653
Abstract: Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular basis remains largely unclear. By combining scRNA‐seq analysis of whole skin‐derived irradiated cells with… read more here.
Keywords: ccr6; cell; cell transcriptomics; single cell ... See more keywords
CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2021.280067
Abstract: The genesis of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is driven by oncogenic co-operation among immunological stimulations and acquired genetic changes. We previously identified recurrent CCR6 mutations in MALT lymphoma, with majority… read more here.
Keywords: ccr6; lymphoma; malt lymphoma; lymphoid tissue ... See more keywords
The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00415
Abstract: CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand, CCL20 and is primarily expressed by leukocytes. Upon ligand binding, CCR6 activates Gαi heterotrimeric G proteins to induce various potential cellular outcomes… read more here.
Keywords: thr residues; ccr6; phosphorylation; ser thr ... See more keywords
TFR Cells Express Functional CCR6 But It Is Dispensable for Their Development and Localization During Splenic Humoral Immune Responses
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.873586
Abstract: Follicular T cells including T follicular helper (TFH) and T follicular regulatory (TFR) cells are essential in supporting and regulating the quality of antibody responses that develop in the germinal centre (GC). Follicular T cell… read more here.
Keywords: ccr6; humoral immune; development; cells express ... See more keywords
Development of a High-Throughput Calcium Mobilization Assay for CCR6 Receptor Coupled to Hydrolase Activity Readout
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020422
Abstract: CCR6 is a chemokine receptor highly implicated in inflammatory diseases and could be a potential therapeutic target; however, no therapeutic agents targeting CCR6 have progressed into clinical evaluation. Development of a high-throughput screening assay for… read more here.
Keywords: ccr6; calcium mobilization; high throughput;