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   Articles with "ccr6" as a keyword



Activation of CCL20 and its receptor CCR6 promotes endometrium preparation for implantation and placenta development during the early pregnancy period in pigs

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recommendations! Published in 2019 at "Developmental and Comparative Immunology"

DOI: 10.1016/j.dci.2018.11.005

Abstract: ABSTRACT The success of implantation and placentation during early pregnancy depends on the intrauterine environment of diverse histotrophs, including nutrients, growth factors, cytokines, and chemokines. Here, we determined the functional role and signal transduction of… read more here.

Keywords: ccl20 receptor; pregnancy; ccl20; ccr6 ... See more keywords

CCR6 signaling inhibits suppressor function of induced-Treg during gut inflammation.

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recommendations! Published in 2018 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2017.10.013

Abstract: CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20. The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non-chemotaxis functions of CCR6 signaling… read more here.

Keywords: induced treg; gut inflammation; ccr6; ccr6 signaling ... See more keywords

Association study of CCR6 rs3093024 with Rheumatoid Arthritis in a Pakistani cohort

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recommendations! Published in 2020 at "Saudi Journal of Biological Sciences"

DOI: 10.1016/j.sjbs.2020.08.045

Abstract: C-C Chemokine receptor 6 (CCR6), an important protein in inflammatory and immunological responses, has been previously reported to be associated with rheumatoid arthritis (RA). Therefore, in order to replicate these findings, a case-control study was… read more here.

Keywords: ccr6 rs3093024; ccr6; study; rs3093024 variant ... See more keywords

CCL20, a direct‐acting pro‐angiogenic chemokine induced by hepatitis C virus (HCV): Potential role in HCV‐related liver cancer

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recommendations! Published in 2018 at "Experimental Cell Research"

DOI: 10.1016/j.yexcr.2018.09.023

Abstract: Abstract The CCL20/CCR6 chemokine/receptor axis has previously been shown to contribute to the initiation and progression of hepatocellular carcinoma (HCC) through the recruitment of CCR6‐positive leukocytes to the tumor microenvironment. In particular, high serum levels… read more here.

Keywords: pro angiogenic; hcc; ccl20; ccl20 direct ... See more keywords
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Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-16820-6

Abstract: Chemokines are important protein-signaling molecules that regulate various immune responses by activating chemokine receptors which belong to the G protein-coupled receptor (GPCR) superfamily. Despite the substantial progression of our structural understanding of GPCR activation by… read more here.

Keywords: protein; ccr6; activation; chemokine receptor ... See more keywords

Migration arrest and transendothelial trafficking of human pathogenic-like Th17 cells are mediated by differentially positioned chemokines

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-57002-6

Abstract: Human Th17/type 17 cells express the chemokine receptor CCR6, but the functions of CCR6 and other chemokine receptors in human type 17 Th cell extravasation have not been fully delineated. Here we show that human… read more here.

Keywords: ccr6; migration; th17; human pathogenic ... See more keywords

#1167 Examination of subsets of CD4+ lymphocyte subpopulations in long-surviving renal transplant patients

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recommendations! Published in 2024 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfae069.1666

Abstract: Subpopulations of CD4+ cells, play a major role in mediation of rejection and tolerance to a renal transplant. This study examined subsets of CD4+ T cells and CD4+CD25+CD127lo Treg in blood of renal graft recipients… read more here.

Keywords: ccr6; pop; treg pop; transplant ... See more keywords

Abstract 4779: Targeting the CCL20-CCR6 axis as a novel opportunity to stimulataneously modulate cancer stem cells and the tumor-immune infiltrate by a dual anti-cancer mechanism

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recommendations! Published in 2017 at "Cancer Research"

DOI: 10.1158/1538-7445.am2017-4779

Abstract: Drugs that target cancer stem cells (CSCs) are thought to be a critical component of any successful therapy against cancer. CSCs are responsible for chemoresistance, metastasis, and ultimately relapse of the cancer, even after an… read more here.

Keywords: ccl20; ccr6; cancer; stem cells ... See more keywords

Single‐cell transcriptomics reveals a senescence‐associated IL‐6/CCR6 axis driving radiodermatitis

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recommendations! Published in 2022 at "EMBO Molecular Medicine"

DOI: 10.15252/emmm.202115653

Abstract: Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular basis remains largely unclear. By combining scRNA‐seq analysis of whole skin‐derived irradiated cells with… read more here.

Keywords: ccr6; cell; cell transcriptomics; single cell ... See more keywords

CCR6 activation links innate immune responses to mucosa-associated lymphoid tissue lymphoma development

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recommendations! Published in 2022 at "Haematologica"

DOI: 10.3324/haematol.2021.280067

Abstract: The genesis of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is driven by oncogenic co-operation among immunological stimulations and acquired genetic changes. We previously identified recurrent CCR6 mutations in MALT lymphoma, with majority… read more here.

Keywords: ccr6; lymphoma; malt lymphoma; lymphoid tissue ... See more keywords

The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function

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recommendations! Published in 2018 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2018.00415

Abstract: CCR6 is a G protein-coupled receptor (GPCR) that recognizes a single chemokine ligand, CCL20 and is primarily expressed by leukocytes. Upon ligand binding, CCR6 activates Gαi heterotrimeric G proteins to induce various potential cellular outcomes… read more here.

Keywords: thr residues; ccr6; phosphorylation; ser thr ... See more keywords