Site‐Specific Polyplex on CCR7 Down‐Regulation and T Cell Elevation for Lymphatic Metastasis Blocking on Breast Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201166
Abstract: Tumor metastasis contributes to high cancer mortality. Tumor cells in lymph nodes (LNs) are difficult to eliminate but underlie uncontrollable systemic metastasis. The CC chemokine receptor 7 (CCR7) is overexpressed in tumor cells and interacts… read more here.
Keywords: metastasis; ccr7; tumor cells; site specific ... See more keywords
CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial–mesenchymal transition and suppressing apoptosis through AKT pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.1039
Abstract: Chemokine and the chemokine receptor have a key role in the tumor progress. Here, we supposed that CCR7 might induce the invasion, migration, and epithelial–mesenchymal transition (EMT) process of breast cancer. In this research, human… read more here.
Keywords: invasion; migration; ccr7; breast cancer ... See more keywords
MiRNALet‐7a mediates prostate cancer PC‐3 cell invasion, migration by inducing epithelial‐mesenchymal transition through CCR7/MAPK pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26595
Abstract: Prostate cancer is one of the most common malignancies in older men. Recent evidence has demonstrated microRNA (miRNA) Let‐7a expression decreased in prostate cancer, while the expression of CC chemokine receptor type 7 (CCR7) increased.… read more here.
Keywords: invasion; ccr7; prostate cancer; cancer ... See more keywords
A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2vma1217-492r
Abstract: Chemokine receptors are considered to belong to the group of G protein‐coupled receptors that use the first transmembrane domain as signal anchor sequence for membrane insertion instead of a cleavable N‐terminal signal sequence. Chemokine recognition… read more here.
Keywords: signal sequence; ccr7; sequence chemokine; receptor ... See more keywords
CCR7 signalosomes are pre-assembled on tips of lymphocyte microvilli in proximity to LFA-1.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.08.014
Abstract: Leukocyte microvilli are elastic actin-rich projections implicated in rapid sensing and penetration across glycocalyx barriers. Microvilli are critical for the capture and arrest of flowing lymphocytes by high endothelial venules (HEVs), the main lymph node… read more here.
Keywords: lymphocyte microvilli; lfa; lfa molecules; ccr7 ... See more keywords
Increased frequency of CCR7+CD4+ T cells from patients with primary Sjögren's syndrome: An indicator of disease activity rather than of damage severity
Sign Up to like & getrecommendations! Published in 2018 at "Cytokine"
DOI: 10.1016/j.cyto.2018.04.015
Abstract: &NA; Expression of CCR7 on T cells has been reported to be associated with the lymphocytic migration and infiltration, which is recognized as a vital part of the pathogenesis of Primary Sjögren's syndrome (pSS). Here,… read more here.
Keywords: disease activity; cd4 cells; ccr7;
RAGE and CCR7 mediate the transmigration of Zika-infected monocytes through the blood-brain barrier.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.08.007
Abstract: Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition… read more here.
Keywords: blood brain; ccr7; zikv; rage ... See more keywords
CCR7 expression in CD19 chimeric antigen receptor-engineered natural killer cells improves migration toward CCL19-expressing lymphoma cells and increases tumor control in mice with human lymphoma.
Sign Up to like & getrecommendations! Published in 2022 at "Cytotherapy"
DOI: 10.1016/j.jcyt.2022.02.006
Abstract: BACKGROUND AIMS Chimeric antigen receptor (CAR) T-cell therapy can be associated with significant toxicities. CAR-engineered natural killer (NK) cells provide a safer alternative while maintaining anti-tumor effects. Activated NK (aNK) cells are a clinical-grade cellular… read more here.
Keywords: receptor; ccr7; tumor; cd19 hank ... See more keywords
Down-regulation of CCR7 via AKT pathway and GATA2 inactivation suppressed trophoblast migration and invasion in recurrent spontaneous abortion
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioz172
Abstract: Abstract The underlying mechanism of the chemokine-C receptor 7 (CCR7) that leads to aberrant trophoblast migration and invasion in recurrent spontaneous abortion (RSA) remains unknown. CCR7 is considered crucial for migration and invasion and has… read more here.
Keywords: trophoblast migration; migration invasion; ccr7; gata2 ... See more keywords
SARS‐CoV‐2 infection in a X‐linked agammaglobulinemia adolescent: An immunological approach to treatment
Sign Up to like & getrecommendations! Published in 2023 at "Pediatric Allergy and Immunology"
DOI: 10.1111/pai.13921
Abstract: To the Editor, A very limited amount of data is present in the literature on SARSCoV2 infection in Xlinked agammaglobulinemia (XLA) patients.1 Moreover, it remains unclear the role of vaccination against SARSCoV2 in these subjects.2… read more here.
Keywords: day; infection; ccr7; treatment ... See more keywords
Trichinella spiralis nurse cell formation is regulated via CCR7+ dendritic cells
Sign Up to like & getrecommendations! Published in 2022 at "Parasite Immunology"
DOI: 10.1111/pim.12938
Abstract: The chemokine receptor CCR7 is a well‐established homing receptor for dendritic cells (DCs) and T‐cells. Interaction with the CCL19 and CCL21 ligands promotes priming of immune responses in lymphoid tissues; however, the mechanism underlying CCR7‐induced… read more here.
Keywords: infection; ccr7; spiralis infection; dendritic cells ... See more keywords