CCR9 and CCL25: A review of their roles in tumor promotion
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29782
Abstract: Chemokines constitute a superfamily of small chemotactic cytokines with functions that are based on interactions with their corresponding receptors. It has been found that, among other functions, chemokines regulate the migratory and invasive abilities of… read more here.
Keywords: review; cancer; ccr9 ccl25; ccr9 ... See more keywords
In-silico guided discovery of novel CCR9 antagonists
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Computer-Aided Molecular Design"
DOI: 10.1007/s10822-018-0113-2
Abstract: Antagonism of CCR9 is a promising mechanism for treatment of inflammatory bowel disease, including ulcerative colitis and Crohn’s disease. There is limited experimental data on CCR9 and its ligands, complicating efforts to identify new small… read more here.
Keywords: novel ccr9; ccr9 antagonists; guided discovery; silico guided ... See more keywords
MLN3126, an antagonist of the chemokine receptor CCR9, ameliorates inflammation in a T cell mediated mouse colitis model
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.04.049
Abstract: ABSTRACT C‐C chemokine receptor 9 (CCR9) is the homing receptor for C‐C motif chemokine ligand 25 (CCL25), and contributes to the maintenance of mucosal immunity and pathogenesis of inflammatory bowel disease (IBD) through the recruitment… read more here.
Keywords: mln3126; colitis model; colitis; ccr9 ... See more keywords
The role of the CCL25-CCR9 axis in beta-cell function: potential for therapeutic intervention in type 2 diabetes.
Sign Up to like & getrecommendations! Published in 2020 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2020.154394
Abstract: BACKGROUND AND PURPOSE Chemokines are known to play essential roles mediating immunity and inflammation in many physiological and pathophysiological processes, with reports linking their action to the development of obesity, insulin resistance and type 2… read more here.
Keywords: islets obese; ccl25; type diabetes; beta cell ... See more keywords
Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren’s syndrome to facilitate their concerted migration
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12852
Abstract: CCR9 + T helper (Th) cells can induce Sjögren‐like symptoms in mice and both CCR9 + Th cells and their ligand CCL25 are increased in the salivary glands of primary Sjögren's syndrome (pSS) patients. Increased… read more here.
Keywords: cxcr3; ccr9 cells; salivary gland; ccr9 ... See more keywords
CCR9 axis inhibition enhances hepatic migration of plasmacytoid DCs and protects against liver injury
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159910
Abstract: Plasmacytoid dendritic cells (pDCs) perform dual proinflammatory and immunosuppressive roles. We recently reported the potential of pDC therapy for treatment of intractable acute liver failure. However, establishment of efficient methods to deliver pDCs to the… read more here.
Keywords: acute liver; ccr9 axis; pdcs; migration ... See more keywords
Mesenchymal Stem Cells Improve the Structure and Function of the Graft-Versus-Host Disease Receptor Thymus: CCR9 Plays an Important Role in Its Homing Thymus
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125307
Abstract: Background: Insufficient thymic function of allogeneic hematopoietic stem cell transplantation (allo-HSCT) receptors results in continuous production of alloreactive T cells, which leads to the development of graft-versus-host disease (GVHD), especially chronic GVHD (cGVHD). We have… read more here.
Keywords: group; thymus; mscs; msc ccr9 ... See more keywords
CCR9 initiates epithelial–mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02320-0
Abstract: Background Osteosarcoma (OS) patients with lung metastasis have poor prognoses, and effective therapeutic strategies for delaying or inhibiting the spread of lung metastasis from the primary OS site are lacking. Hence, it is critical to… read more here.
Keywords: lung metastasis; ccr9; wnt catenin; metastasis ... See more keywords
Clinical significance and prospective molecular mechanism of C-C motif chemokine receptors in patients with early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Reports"
DOI: 10.3892/or.2019.7277
Abstract: The present study aimed to determine the clinical significance and potential molecular mechanisms of C-C motif chemokine receptor (CCR) genes in patients with early-stage pancreatic ductal adenocarcinoma (PDAC). The transcriptomic, survival and clinical data of… read more here.
Keywords: patients early; ccr9; early stage; stage pdac ... See more keywords
CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.13844
Abstract: Background CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor, interacts with its exclusive ligand CCL25 to promote tumor proliferation and metastasis. However, the effect of CCR9 on salivary adenoid cystic carcinoma (SACC) malignant behavior… read more here.
Keywords: ccl25; pi3k akt; sacc; ccl25 ccr9 ... See more keywords