P0506 AZD7798, a monoclonal antibody depleting CCR9+ T cells, with the potential to target hard-to-treat small bowel Crohn’s disease
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjae190.0680
Abstract: Crohn’s disease (CD) can affect any part of the gastrointestinal tract, but about 30% of patients have inflammation restricted to the ileum. In clinical trials, patients are typically enrolled irrespective of the disease localisation, with… read more here.
Keywords: disease; antibody; small bowel; ccr9 cells ... See more keywords
Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren’s syndrome to facilitate their concerted migration
Sign Up to like & getrecommendations! Published in 2019 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12852
Abstract: CCR9 + T helper (Th) cells can induce Sjögren‐like symptoms in mice and both CCR9 + Th cells and their ligand CCL25 are increased in the salivary glands of primary Sjögren's syndrome (pSS) patients. Increased… read more here.
Keywords: cxcr3; ccr9 cells; salivary gland; ccr9 ... See more keywords