Biomimetic Nano‐Regulator that Induces Cuproptosis and Lactate‐Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202400204
Abstract: Herein, a ccRCC targeting nanodrug is designed to enhance chemodynamic therapy (CDT) as well as activate cuproptosis and tumor immunotherapy via ccRCC cell membrane modifying CuO@Gd2O3 yolk‐like particles (CGYL) loaded with lactate oxidase (LOx) (mCGYL‐LOx).… read more here.
Keywords: ccrcc; mcgyl lox; cuproptosis; cell ... See more keywords
Fe-S Protein FDX1 Triggers Tumor-Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced science"
DOI: 10.1002/advs.202518323
Abstract: Activation of cytosolic nucleic acid-sensing pathways represents a promising strategy to convert immunologically "cold" tumors into inflamed ones. Iron-sulfur (Fe-S) enzymes are critical regulators of innate immunity and nucleic acid sensing, yet their roles in… read more here.
Keywords: nucleic acid; ccrcc; immunity; innate immunity ... See more keywords
miR‐122 promotes metastasis of clear‐cell renal cell carcinoma by downregulating Dicer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31050
Abstract: Although overall downregulation of microRNAs (miRNAs) is a general feature of clear‐cell renal cell carcinoma (ccRCC), several miRNAs are consistently upregulated, among which miR‐122 was markedly increased in ccRCC tissues. Our study aims to determine… read more here.
Keywords: cell renal; ccrcc; dicer; mir 122 ... See more keywords
Etiologic heterogeneity of clear‐cell and papillary renal cell carcinoma in the Netherlands Cohort Study
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DOI: 10.1002/ijc.33193
Abstract: At present, mostly case‐control and retrospective studies have investigated the association between etiologic risk factors and the development of histologic subtypes of renal cell carcinoma (RCC). Therefore, we assessed the heterogeneity between body mass index… read more here.
Keywords: risk; ccrcc; heterogeneity; prcc risk ... See more keywords
Special issue “The advance of solid tumor research in China”: Multi‐omics analysis based on 1311 clear cell renal cell carcinoma samples identifies a glycolysis signature associated with prognosis and treatment response
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34121
Abstract: In clear cell renal cell carcinoma (ccRCC), glycolysis is enhanced mainly because of the increased expression of key enzymes in glycolysis. Hence, the discovery of new molecular biomarkers for glycolysis may help guide and establish… read more here.
Keywords: cell renal; cell; renal cell; ccrcc ... See more keywords
Genome‐wide screening and cohorts validation identifying novel lncRNAs as prognostic biomarkers for clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29478
Abstract: Clear cell renal cell carcinoma (ccRCC) is the main subtype of renal cell carcinoma with varied prognosis. We aimed to identify and assess the possible prognostic long noncoding RNA (lncRNA) biomarkers. LncRNAs expression data and… read more here.
Keywords: cell renal; renal cell; ccrcc; cell carcinoma ... See more keywords
G Protein γ subunit 7 loss contributes to progression of clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28597
Abstract: Clear cell renal cell carcinoma (ccRCC) is a common urinary neoplasm, looking for useful candidates to establish scientific foundation for the therapy of ccRCC is urgent. We downloaded genomic profiles of GSE781, GSE6244, GSE53757, and… read more here.
Keywords: cell renal; ccrcc; expression; gene ... See more keywords
Identification of methylation‐driven genes related to prognosis in clear‐cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29046
Abstract: With the participation of the existing treatment methods, the prognosis of advanced clear‐cell renal cell carcinoma (ccRCC) is poor. More evidence indicates the presence of methylation in ccRCC cancer cells, but there is a lack… read more here.
Keywords: methylation; ccrcc; prognosis; methylation driven ... See more keywords
GBP2 serves as a novel prognostic biomarker and potential immune microenvironment indicator in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23447
Abstract: Since the application of immune checkpoint therapy (ICT) has gradually become a new strategy for clear cell renal cell carcinoma (ccRCC) treatment, biomarkers that predict the individual response to ICT is needed. This study aimed… read more here.
Keywords: gbp2 expression; ccrcc; cell; indicator ... See more keywords
Juxtatumoral perinephric fat analysis in clear cell renal cell carcinoma
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DOI: 10.1007/s00261-018-1848-x
Abstract: PurposeThe purpose of the study was to evaluate the feasibility of using contrast-enhanced computed tomography (CECT)-based texture analysis (CTTA) metrics to differentiate between juxtatumoral perinephric fat (JPF) surrounding low-grade (ISUP 1–2) versus high-grade (ISUP 3–4)… read more here.
Keywords: ccrcc; grade; analysis; perinephric fat ... See more keywords
The percentage abundance of sarcomatoid component has a prognostic role in grade 4 non-metastatic clear cell-renal carcinoma
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DOI: 10.1007/s00345-025-05630-4
Abstract: Sarcomatoid dedifferentiation represents one of the most aggressive features of clear cell renal cell carcinoma (ccRCC). In this study we evaluated whether grade 4-ccRCC subclassification based on the intratumoral abundance of sarcomatoid features could have… read more here.
Keywords: ccrcc; sarcomatoid component; abundance sarcomatoid; component ... See more keywords