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   Articles with "ccrf cem" as a keyword



Design, synthesis, anticancer, and antibacterial evaluation of some quinazolinone-based derivatives as DHFR inhibitors.

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recommendations! Published in 2023 at "Drug development research"

DOI: 10.1002/ddr.22060

Abstract: Two series of quinazolinone derivatives were designed and synthesized as dihydrofolate reductase (DHFR) inhibitors. All compounds were evaluated for their antibacterial and antitumor activities. Antibacterial activity was evaluated against three strains of Gram-positive and Gram-negative… read more here.

Keywords: quinazolinone; compound; ccrf cem; activity ... See more keywords

Apoptotic effect of resveratrol on human T‐ALL cell line CCRF‐CEM is unlikely exerted through alteration of BAX and BCL2 promoter methylation

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recommendations! Published in 2018 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.27333

Abstract: One of the fundamental barriers leading to failure of leukemia therapy is the resistance against conventional chemotherapies, common modality used to cure leukemia. Having the potential to trigger apoptosis in various human leukemia cell lines,… read more here.

Keywords: bax; resveratrol; methylation; ccrf cem ... See more keywords

Cytotoxicity of the crude extract and constituents of the bark of Fagara tessmannii towards multi-factorial drug resistant cancer cells.

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recommendations! Published in 2019 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2019.01.031

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Fagara tessmannii Engl. is an African medicinal plant used in Cameroonian traditional medicine to treat various types of cancers. AIM OF THE STUDY This work was designed to determine the cytotoxicity of the… read more here.

Keywords: ccrf cem; crude extract; fagara tessmannii; cem cells ... See more keywords

2-Deoxyglycoside conjugates of lupane triterpenoids with high cytotoxic activity - synthesis, activity, and pharmacokinetic profile.

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recommendations! Published in 2019 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.9b00565

Abstract: A set of 41 glycosidic conjugates of pentacyclic triterpenes was synthesized in order to improve the solubility of highly cytotoxic parent compounds. Their in vitro cytotoxic activity was evaluated in 25 cancer cell lines and… read more here.

Keywords: ccrf cem; pharmacokinetic profile; compound; activity ... See more keywords

P-gp quantification for cell resistance studies in leukemia cells using the innovative LightSpot-FL-1 fluorescent conjugate

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-03370-4

Abstract: Multidrug resistance proteins contribute to chemotherapy resistance in various cancers. Among them, the P-glycoprotein (P-gp) has been the most investigated. These works aim to evaluate the efficacy of the new fluorescent tracer LightSpot-FL-1 for quantifying… read more here.

Keywords: resistance; fluorescent; ccrf cem; cell ... See more keywords
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Potential biomedical reuse of vegetative residuals from mycorrhized grapevines subjected to warming

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recommendations! Published in 2019 at "Archives of Agronomy and Soil Science"

DOI: 10.1080/03650340.2018.1564907

Abstract: ABSTRACT Grapevine leaves are widely discarded in open fields despite their known antioxidant properties. We tested the cytotoxicity of leaf extracts from three clones (CL-260, CL-1048, CL-8) of Vitis vinifera L. cv. Tempranillo against four… read more here.

Keywords: potential biomedical; htb; ccrf cem; cytotoxicity leaf ... See more keywords

Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation

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recommendations! Published in 2024 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2024.2367139

Abstract: Abstract Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction, focusing on structural modifications within the aromatic bridge connecting… read more here.

Keywords: click estradiol; anticancer; estradiol dimers; ccrf cem ... See more keywords

Ginsenoside 24-OH-PD from red ginseng inhibits acute T-lymphocytic leukaemia by activating the mitochondrial pathway

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recommendations! Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0285966

Abstract: Ginsenoside 24-hydroxy-ginsengdiol (24-OH-PD), extracted from red ginseng, is a novel diol-type ginsenoside, strongly inhibits the growth of human T-cell acute lymphoblastic leukaemia (T-ALL) CCRF-CEM cells. Our research aimed at investigating the mechanism underlying this inhibition.… read more here.

Keywords: ccrf cem; apoptosis; ginsenoside; cem cells ... See more keywords