C-C Chemokine receptor-like 2 (CCRL2) acts as coreceptor for human immunodeficiency virus-2.
Sign Up to like & getrecommendations! Published in 2020 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbaa333
Abstract: INTRODUCTION Most of the typical chemokine receptors (CKRs) have been identified as coreceptors for a variety of human and simian immunodeficiency viruses (HIVs and SIVs). This study evaluated CCRL2 to examine if it was an… read more here.
Keywords: immunodeficiency; ccrl2; hiv siv; hiv ... See more keywords
The atypical receptor CCRL2 is required for CXCR2-dependent neutrophil recruitment and tissue damage.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-777680
Abstract: CCRL2 is a 7-transmembrane domain receptor that shares structural and functional similarities with the family of atypical chemokine receptors (ACKRs). CCRL2 is upregulated by inflammatory signals and, unlike other ACKRs, it is not a chemoattractant-scavenging… read more here.
Keywords: ccrl2; atypical receptor; neutrophil recruitment; receptor ccrl2 ... See more keywords
Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0280590
Abstract: C-C motif chemokine receptor-like 2 (CCRL2) is a non-signaling 7 transmembrane receptor that binds chemotactic ligands to shape leukocyte recruitment to sites of inflammation. However, there is a lack of consensus on the ligands that… read more here.
Keywords: motif chemokine; function; chemokine receptor; cxcl8 ... See more keywords
CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine.
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281444
Abstract: Better understanding of the biology of resistance to DNA methyltransferase (DNMT) inhibitors (DNMTi) is required to identify therapies that can improve their efficacy for patients with highrisk myelodysplastic syndrome (MDS). CCRL2 is an atypical chemokine… read more here.
Keywords: mds; cells azacitidine; sensitivity; ccrl2 ... See more keywords
The Atypical Receptor CCRL2 (C-C Chemokine Receptor-Like 2) Does Not Act As a Decoy Receptor in Endothelial Cells
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DOI: 10.3389/fimmu.2017.01233
Abstract: C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family. ACKRs bind chemokines but do not activate G protein-dependent signaling or cell functions. ACKRs were… read more here.
Keywords: ccrl2; receptor like; receptor; ability ... See more keywords