Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene
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DOI: 10.26508/lsa.202101019
Abstract: Frequent deletions impacting the FRA4F fragile site leads to the oncogenic overexpression of the corresponding CCSER1 gene, through the deletion of the TMSB4XP8 pseudogene. The ensuing CCSER1 overexpression elicits mitotic instability, targetable with aurora kinase… read more here.
Keywords: ccser1 gene; gene; pseudogene; fragile site ... See more keywords