Diversification of CD1 Molecules Shapes Lipid Antigen Selectivity
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msab022
Abstract: Abstract Molecular studies of host–pathogen evolution have largely focused on the consequences of variation at protein–protein interaction surfaces. The potential for other microbe-associated macromolecules to promote arms race dynamics with host factors remains unclear. The… read more here.
Keywords: cd1 molecules; cd1; diversification cd1; lipid binding ... See more keywords
The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading.
Sign Up to like & getrecommendations! Published in 2019 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.15368.1
Abstract: Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules. The hydrophobic lipid antigens are embedded in membranes… read more here.
Keywords: cd1 molecules; cd1d; sapb; antigen ... See more keywords