CD137 Signaling Regulates Acute Colitis via RALDH2-Expressing CD11b-CD103+ DCs.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.103
Abstract: CD137, a potent costimulatory receptor for CD8+ T cells, is expressed in various non-T cells, but little is known about its regulatory functions in these cells. In this study, we show that CD137 signaling, specifically in… read more here.
Keywords: cd103 dcs; cd11b cd103; cd103; cd137 signaling ... See more keywords
Significance of IL-17A-producing CD8+CD103+ skin resident memory T cells in psoriasis lesion and their possible relationship to clinical course.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2019.06.002
Abstract: BACKGROUND A number of studies have shown the relationship between the pathogenesis of psoriasis and skin resident memory T (TRM) cells. OBJECTIVE To investigate the cytokine profile of TRM cells from skin lesions of psoriasis… read more here.
Keywords: psoriasis; cd103; trm cells; cd8 cd103 ... See more keywords
Neonatal mice possess two phenotypically and functionally distinct lung-migratory CD103+ dendritic cell populations following respiratory infection
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/mi.2017.28
Abstract: The CD103+ subset of lung-migratory dendritic cells (DCs) plays an important role in the generation of CD8+ T cell responses following respiratory infection. Here, we demonstrate that the dependence on CD103+ DCs for stimulation of… read more here.
Keywords: dcs; cd103; respiratory infection; neonatal mice ... See more keywords
March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05572-z
Abstract: In transplantation, donor dendritic cells (do-DCs) initiate the alloimmune response either by direct interaction with host T cells or by transferring intact donor MHC to host DCs. However, how do-DCs can be targeted for improving… read more here.
Keywords: alloimmunity; dcs; cd103; donor mhc ... See more keywords
γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.11.028
Abstract: BACKGROUND & AIMS Excessive shedding of apoptotic enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. Based on their cytolytic capacity and surveillance behavior, we investigated whether… read more here.
Keywords: release; intraepithelial lymphocytes; microscopy; cd103 ... See more keywords
CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncoimmunology"
DOI: 10.1080/2162402x.2017.1338230
Abstract: ABSTRACT Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial T… read more here.
Keywords: benefit; cervical cancer; cd103; cell ... See more keywords
Lactobacillus brevis KB290 With Vitamin A Ameliorates Murine Intestinal Inflammation Associated With the Increase of CD11c+ Macrophage/CD103- Dendritic Cell Ratio.
Sign Up to like & getrecommendations! Published in 2018 at "Inflammatory bowel diseases"
DOI: 10.1093/ibd/izx003
Abstract: Background The ratio of colonic anti-inflammatory CD11c+ macrophages (MPs) to inflammatory CD103- dendritic cells (DCs) plays pivotal roles in intestinal inflammation. Little is known about how the ratio is regulated by lactic acid bacteria (LAB)… read more here.
Keywords: cd11c; intestinal inflammation; cd103; ratio ... See more keywords
OP0042 BLOCKING OF CD103+ TISSUE RESIDENT MEMORY T CELLS (TRM) AS A THERAPEUTIC STRATEGY IN SJOGREN’S SYNDROME
Sign Up to like & getrecommendations! Published in 2021 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2021-eular.2649
Abstract: Tissue-resident memory T cells (TRM), are a recently identified T cells population featuring tissue localization and expression of markers of tissue homing, CD69 and CD103. Recently, the expansion of CD8+ TRMs and their involvement in… read more here.
Keywords: cd8; pss; tissue; resident memory ... See more keywords
Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004877
Abstract: Purpose CD103, an integrin specifically expressed on the surface of cancer-reactive T cells, is significantly increased during successful immunotherapy across human malignancies. In this study, we describe the generation and zirconium-89 (89Zr) radiolabeling of monoclonal… read more here.
Keywords: cd103; pet; human cd103; 89zr anti ... See more keywords
Abstract 4984: Where do the T lymphocytes go in prostate cancer: Correlation with CD103, CD39 expression and clinical pathological parameters
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-4984
Abstract: Introduction: Many solid tumors such as prostate cancer have shown limited response to immunotherapy treatment. Whether this is due to absence of tumor specific antigens or poor immune infiltrate, the exact mechanism is not well… read more here.
Keywords: cd4 cd8; cd103; prostate cancer; cd39 ... See more keywords
CD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02989
Abstract: Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance. In the stomach, efficient DC surveillance of the epithelial… read more here.
Keywords: gastric dcs; adhesion; cd103; integrin ... See more keywords