CD11b regulates the Treg/Th17 balance in murine arthritis via IL‐6
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646565
Abstract: Th17 cells are often associated with autoimmunity and been shown to be increased in CD11b−/− mice. Here, we examined the role of CD11b in murine collagen‐induced arthritis (CIA). C57BL/6 and CD11b−/− resistant mice were immunized… read more here.
Keywords: cd11b mice; treg th17; cd11b; mice ... See more keywords
Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747073
Abstract: Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental… read more here.
Keywords: cd11b; cell; helminth infection; cd11b dcs ... See more keywords
Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation
Sign Up to like & getrecommendations! Published in 2019 at "Mammalian Genome"
DOI: 10.1007/s00335-019-09819-y
Abstract: Genome-wide association studies (GWAS) and functional genomic analyses have implicated several ITGAM (CD11b) single-nucleotide polymorphisms (SNPs) in the development of SLE and other disorders. ITGAM encodes the αM chain of the β2 integrin Mac-1, a… read more here.
Keywords: rs1143679; cell proliferation; cd11b; itgam cd11b ... See more keywords
Preclinical ImmunoPET Imaging of Glioblastoma-Infiltrating Myeloid Cells Using Zirconium-89 Labeled Anti-CD11b Antibody
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-019-01427-1
Abstract: Purpose Glioblastoma is a lethal brain tumor, heavily infiltrated by tumor-associated myeloid cells (TAMCs). TAMCs are emerging as a promising therapeutic target as they suppress anti-tumor immune responses and promote tumor cell growth. Quantifying TAMCs… read more here.
Keywords: myeloid cells; cd11b antibody; cd11b; anti cd11b ... See more keywords
Effects of intestinal nematode treatment on CD11b activation state in an EAE mouse model of multiple sclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.08.004
Abstract: The experimental autoimmune encephalomyelitis (EAE) animal model of Multiple Sclerosis (MS) is characterized by episodic neurologic dysfunction arising as a consequence of perivascular mononuclear cell infiltration and demyelination in the CNS. Leukocyte integrins, which are… read more here.
Keywords: eae; cd11b; multiple sclerosis; activation state ... See more keywords
Expansion of CD11b+Ly‐6C+ myeloid‐derived suppressor cells (MDSCs) driven by galectin‐9 attenuates CVB3‐induced myocarditis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.01.013
Abstract: &NA; Galectin‐9 is known to play a role in the modulation of innate and adaptive immunity to ameliorate CVB3‐induced myocarditis. In the present study, we found that galectin‐9 induced the expansion of CD11b+Ly‐6C+ myeloid‐derived suppressor… read more here.
Keywords: expansion cd11b; cvb3 induced; induced myocarditis; cd11b ... See more keywords
Targeting Infiltrating Myeloid Cells in Gastric Cancer Using a Pretargeted Imaging Strategy Based on Bio-Orthogonal Diels-Alder Click Chemistry and Comparison with 89Zr-Labeled Anti-CD11b Positron Emission Tomography Imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00745
Abstract: Gastric cancer (GC) is a common cancer worldwide, with high incidence and mortality rates. Therefore, early and precise diagnosis is critical to improving GC prognosis. Tumor-associated myeloid cells infiltrate the tumor microenvironment (TME) and can… read more here.
Keywords: myeloid cells; chemistry; cd11b; anti cd11b ... See more keywords
Liver X receptors regulate hepatic F4/80+CD11b+ Kupffer cells/macrophages and innate immune responses in mice
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27615-7
Abstract: The liver X receptors (LXRs), LXRα and LXRβ, are nuclear receptors that regulate lipid homeostasis. LXRs also regulate inflammatory responses in cultured macrophages. However, the role of LXRs in hepatic immune cells remains poorly characterized.… read more here.
Keywords: cells macrophages; kupffer cells; liver receptors; cd11b ... See more keywords
Cardiac inflammatory CD11b/c cells exert a protective role in hypertrophied cardiomyocyte by promoting TNFR2- and Orai3- dependent signaling
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-42452-y
Abstract: Early adaptive cardiac hypertrophy (EACH) is initially a compensatory process to optimize pump function. We reported the emergence of Orai3 activity during EACH. This study aimed to characterize how inflammation regulates store-independent activation of Orai3-calcium… read more here.
Keywords: inflammatory cd11b; orai3 dependent; cd11b; tnfr2 orai3 ... See more keywords
210: THE MOBILIZATION OF SPLENIC RESERVOIR MDSCS IN SEPSIS-INDUCED MYOCARDIAL INJURY
Sign Up to like & getrecommendations! Published in 2019 at "Critical Care Medicine"
DOI: 10.1097/01.ccm.0000550965.62879.d4
Abstract: Learning Objectives: Sepsis induced myocardial injury is not rare in intensive care unit.We supposed that splenic reservoir MDSCs mobilized to myocardial tissue and lead to cardiac insufficiency. Methods: Sepsis with cardiac injury and cardiac dysfunction… read more here.
Keywords: clp; sepsis; control; cd11b ... See more keywords
Exploiting species specificity to understand the tropism of a human-specific toxin
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.aax7515
Abstract: Overcoming the species specificity of the MRSA toxin LukAB with a novel mouse model establishes a role for LukAB in vivo. Many pathogens produce virulence factors that are specific toward their natural host. Clinically relevant… read more here.
Keywords: species specificity; lukab; cd11b; toxin ... See more keywords