Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.059
Abstract: The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis,… read more here.
Keywords: cd11c macrophages; insulin resistance; dectin; absence myd88 ... See more keywords
Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42665
Abstract: Immune cell accumulation in adipose tissue (AT) is associated with the development of AT inflammation, resulting in metabolic dysfunction. Circulating immune cell patterns may reflect immune cell accumulation in expanding AT. However, data linking human… read more here.
Keywords: immune cell; monocytes associated; associated cd11c; cd11c macrophages ... See more keywords
CD11c+ macrophages are proangiogenic and necessary for experimental choroidal neovascularization
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.168142
Abstract: Patients with neovascular AMD (nAMD) suffer vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Macrophages are found in CNV lesions from patients with nAMD. Additionally, Ccr2–/– mice, which lack classical monocyte–derived macrophages, show reduced… read more here.
Keywords: cd11c; spp1 macrophages; choroidal neovascularization; cd11c macrophages ... See more keywords