Antiproliferative activity of (R)-4'-methylklavuzon on hepatocellular carcinoma cells and EpCAM+/CD133+ cancer stem cells via SIRT1 and Exportin-1 (CRM1) inhibition.
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DOI: 10.1016/j.ejmech.2019.07.024
Abstract: Cytotoxic effects of (R)-4'-methylklavuzon were investigated on hepatocellular carcinoma cells (HuH-7 and HepG2) and HuH-7 EpCAM+/CD133+ cancer stem cells. IC50 of (R)-4'-methylklavuzon was found as 1.25 μM for HuH-7 parental cells while it was found as… read more here.
Keywords: epcam cd133; hepatocellular carcinoma; cancer stem; cd133 cancer ... See more keywords
Transforming growth factor-β makes the key characteristics of the proteome CD133- differentiated cells closer to CD133+ cancer stem cells of glioblastoma
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DOI: 10.1093/annonc/mdz447.024
Abstract: Abstract Background Invasive growth of glioblastoma multiforme (GBM) is associated with CD133 + cancer stem cells (CSCs) and differentiated CD133- glioblastoma cells (DGCs) formed under the influence of transforming growth factor (TGF-β). The aim of… read more here.
Keywords: cd133; growth; cd133 cancer; stem cells ... See more keywords