CD137 Protein Expression Pattern Determines the Functional Role of Galectin‐9 in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23838
Abstract: The rapid advancement of single‐cell sequencing technology has generated extensive data, providing critical resources for colorectal cancer (CRC) research. This study conducts a detailed analysis of CRC single‐cell sequencing data to develop a novel clinical… read more here.
Keywords: galectin; cd137; colorectal cancer; crc ... See more keywords
CD34+ and CD34− MM cells show different immune-checkpoint molecule expression profiles: high expression of CD112 and CD137 ligand on CD34+ MM cells
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Hematology"
DOI: 10.1007/s12185-024-03867-0
Abstract: Despite the introduction of new drugs, multiple myeloma (MM) still remains incurable. We previously reported that CD34+ MM cells, which are clonogenic and self-renewing, are therapy-resistant and persist as a major component of minimal residual… read more here.
Keywords: cd137; cd34 cells; immune checkpoint; cd34 ... See more keywords
The Activation Marker CD137 (4-1BB) Identifies a Highly Active Subset of Donor Lymphocytes Against Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.677
Abstract: Background Donor lymphocyte infusion is an effective treatment for AML relapse post-transplant, but it has the risk of inducing graft versus host disease (GVHD). Isolating and expanding a subset of lymphocytes that contains antigen-specific T… read more here.
Keywords: activation; cd137; pbmc; unselected cells ... See more keywords
Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/2344239
Abstract: Objective The role of T cells in the pathogenesis of systemic lupus erythematosus (SLE) has recently gained attention. Costimulatory molecules are membrane proteins strictly associated with T-cell receptor (TCR), acting by activating or inhibiting T… read more here.
Keywords: sle; cd137 cells; disease activity; sle patients ... See more keywords
Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-2918
Abstract: Abstract Purpose: CD137 molecule is expressed by activated lymphocytes, and in patients with cancer identifies the tumor-reactive T cells. In solid tumors, high levels of circulating CD137+ T cells are associated with the clinical response… read more here.
Keywords: cd137 cells; immunotherapy; cd137; pd1 ... See more keywords
Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-0893
Abstract: The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the potential to reinvigorate potent antitumor immunity either alone or in… read more here.
Keywords: antitumor immunity; cd137; monoclonal antibody; receptor ... See more keywords
Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-614
Abstract: CD137 (4-1BB) is a member of the TNFR family, whose expression is induced on antigen-primed T cells and that mediates potent costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic… read more here.
Keywords: cd137 1bb; cd137; physically associated; antitumor effects ... See more keywords
A single dose of a CD137 antibody-drug conjugate protects nonhuman primate allogeneic HCT recipients against acute GVHD.
Sign Up to like & getrecommendations! Published in 2025 at "Blood"
DOI: 10.1182/blood.2024027239
Abstract: Rapid CD137 upregulation on alloreactive T-cells upon allogeneic stimulation suggests that their selective elimination could prevent acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (HCT). Here, we developed a novel aGVHD prophylactic regimen… read more here.
Keywords: cd137; single dose; cd137 adc; hct ... See more keywords
First-in-human study (FIH) of FS222, a next-generation tetravalent PD-L1/CD137 bispecific antibody: Safety, pharmacodynamics (PD), and antitumor activity in patients (pts) with advanced solid tumors including PD-1 refractory melanoma.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2024.42.16_suppl.2505
Abstract: 2505 Background: Most pts receiving immune checkpoint inhibitors do not respond to treatment or relapse. FS222 is a novel affinity optimized, tetravalent bispecific PD-L1/CD137 antibody. FS222’s structure allows for potent, PD-L1-dependent, CD137 activation across a… read more here.
Keywords: cd137; advanced solid; antibody; solid tumors ... See more keywords
Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.571964
Abstract: The potent costimulatory effect of CD137 has been implicated in several murine autoimmune disease models. CD137 costimulates and polarizes antigen-specific T cells toward a potent Th1/Tc1 response, and is essential for the development of experimental… read more here.
Keywords: cd137 cells; expressing cells; identification cd137; multiple sclerosis ... See more keywords
The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.918837
Abstract: Autoimmunity involves a loss of immune tolerance to self-proteins due to a combination of genetic susceptibility and environmental provocation, which generates autoreactive T and B cells. Genetic susceptibility affects lymphocyte autoreactivity at the level of… read more here.
Keywords: linkage studies; autoimmunity; susceptibility; tolerance ... See more keywords