The Activation Marker CD137 (4-1BB) Identifies a Highly Active Subset of Donor Lymphocytes Against Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.677
Abstract: Background Donor lymphocyte infusion is an effective treatment for AML relapse post-transplant, but it has the risk of inducing graft versus host disease (GVHD). Isolating and expanding a subset of lymphocytes that contains antigen-specific T… read more here.
Keywords: activation; cd137; pbmc; unselected cells ... See more keywords
Membrane and Soluble CD137 in Systemic Lupus Erythematosus: Role as Biomarkers for Disease Activity
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Immunology Research"
DOI: 10.1155/2023/2344239
Abstract: Objective The role of T cells in the pathogenesis of systemic lupus erythematosus (SLE) has recently gained attention. Costimulatory molecules are membrane proteins strictly associated with T-cell receptor (TCR), acting by activating or inhibiting T… read more here.
Keywords: sle; cd137 cells; disease activity; sle patients ... See more keywords
Circulating CD137+ T Cells Correlate with Improved Response to Anti-PD1 Immunotherapy in Patients with Cancer
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DOI: 10.1158/1078-0432.ccr-21-2918
Abstract: Abstract Purpose: CD137 molecule is expressed by activated lymphocytes, and in patients with cancer identifies the tumor-reactive T cells. In solid tumors, high levels of circulating CD137+ T cells are associated with the clinical response… read more here.
Keywords: cd137 cells; immunotherapy; cd137; pd1 ... See more keywords
Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity
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DOI: 10.1158/1535-7163.mct-19-0893
Abstract: The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the potential to reinvigorate potent antitumor immunity either alone or in… read more here.
Keywords: antitumor immunity; cd137; monoclonal antibody; receptor ... See more keywords
Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-614
Abstract: CD137 (4-1BB) is a member of the TNFR family, whose expression is induced on antigen-primed T cells and that mediates potent costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic… read more here.
Keywords: cd137 1bb; cd137; physically associated; antitumor effects ... See more keywords
Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.571964
Abstract: The potent costimulatory effect of CD137 has been implicated in several murine autoimmune disease models. CD137 costimulates and polarizes antigen-specific T cells toward a potent Th1/Tc1 response, and is essential for the development of experimental… read more here.
Keywords: cd137 cells; expressing cells; identification cd137; multiple sclerosis ... See more keywords
The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.918837
Abstract: Autoimmunity involves a loss of immune tolerance to self-proteins due to a combination of genetic susceptibility and environmental provocation, which generates autoreactive T and B cells. Genetic susceptibility affects lymphocyte autoreactivity at the level of… read more here.
Keywords: linkage studies; autoimmunity; susceptibility; tolerance ... See more keywords
Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1113904
Abstract: Background LL-37 is the only member of the cathelicidin family of antimicrobial peptides in humans and is an autoantigen in several autoimmune diseases and in acute coronary syndrome (ACS). In this report, we profiled the… read more here.
Keywords: cell; coronary syndrome; acute coronary; cell response ... See more keywords
CD137L-macrophage induce lymphatic endothelial cells autophagy to promote lymphangiogenesis in renal fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.66781
Abstract: Renal lymphangiogenesis is a new field of international nephrology in recent years and plays an important role in the progression of chronic renal disease. CD137 was originally described as a surface molecule present on activated… read more here.
Keywords: cd137l; cd137; lymphangiogenesis; lymphatic endothelial ... See more keywords