Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-614
Abstract: CD137 (4-1BB) is a member of the TNFR family, whose expression is induced on antigen-primed T cells and that mediates potent costimulatory signals upon ligation by CD137L or agonist monoclonal antibodies. CD137 agonists attain immunotherapeutic… read more here.
Keywords: cd137 1bb; cd137; physically associated; antitumor effects ... See more keywords
CD137 (4-1BB)-Based Cancer Immunotherapy on Its 25th Anniversary.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-22-1029
Abstract: SIGNIFICANCE CD137 (4-1BB) is a costimulatory receptor of T and natural killer lymphocytes whose activity can be exploited in cancer immunotherapy strategies as discovered 25 years ago. Following initial attempts that met unacceptable toxicity, new… read more here.
Keywords: cd137 1bb; cancer; 1bb based; cancer immunotherapy ... See more keywords