CD137L promotes immune surveillance in melanoma via HLTF regulation
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63338-w
Abstract: Immune checkpoint blockers (ICBs) have demonstrated substantial efficacy across various malignancies, yet the benefits of ICBs are limited to a subset of patients. Therefore, it is essential to identify novel therapeutic targets. By integrating multi-omics… read more here.
Keywords: immune checkpoint; cd137l expression; melanoma; cd137l ... See more keywords
Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11208-x
Abstract: Abstractp53 encodes a transcription factor that transactivates downstream target genes involved in tumour suppression. Although osteosarcoma frequently has p53 mutations, the role of p53 in osteosarcomagenesis is not fully understood. To explore p53-target genes comprehensively… read more here.
Keywords: p53 target; cd137l; target; immune response ... See more keywords
CD137L and CD4 T cells limit BCL6‐expressing pre‐germinal center B cell expansion and BCL6‐driven B cell malignancy
Sign Up to like & getrecommendations! Published in 2022 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12578
Abstract: Aberrant expression of the proto‐oncogene BCL6 is a driver of tumorigenesis in diffuse large B cell lymphoma (DLBCL). Mice overexpressing BCL6 from the B cell‐specific immunoglobulin heavy chain μ intron promoter (Iμ‐Bcl6Tg/+) develop B cell… read more here.
Keywords: cell; cd4 cells; cd4; cd137l ... See more keywords
Single-cell analysis reveals an important role of CD137L+ macrophages in the host response to uropathogenic Escherichia coli infection in the bladder
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1013543
Abstract: Uropathogenic Escherichia coli (UPEC) typically trigger rapid and robust innate immune responses in the bladder. In order to identify the key facets of the host response that influence pathogen clearance and tissue damage, single-cell RNA… read more here.
Keywords: cd137l macrophages; response; upec infection; infection ... See more keywords
MD Simulation Reveals a Trimerization-Enhanced Interaction of CD137L with CD137
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26051903
Abstract: CD137 is a prominent costimulatory molecule of the tumor necrosis factor (TNF) receptor superfamily that activates T cells through a complex bidirectional signaling process involving CD137L. The clinical value of immunotherapies underscores the potential of… read more here.
Keywords: cd137; reveals trimerization; trimerization enhanced; simulation reveals ... See more keywords
CD137L-macrophage induce lymphatic endothelial cells autophagy to promote lymphangiogenesis in renal fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.66781
Abstract: Renal lymphangiogenesis is a new field of international nephrology in recent years and plays an important role in the progression of chronic renal disease. CD137 was originally described as a surface molecule present on activated… read more here.
Keywords: cd137l; cd137; lymphangiogenesis; lymphatic endothelial ... See more keywords