CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31030
Abstract: Binding of lipopolysaccharide (LPS) to CD14 is required for its cellular effects via TLR4. A role of LPS/TLR4-mediated signaling in activated hepatic stellate cells (aHSCs), the major fibrogenic cells, in liver fibrosis has been reported.… read more here.
Keywords: inflammation; cd14; cd14 required; expression ... See more keywords
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.047
Abstract: Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism of xenograft rejection. We hypothesized that complement component C5 and TLR co-receptor CD14… read more here.
Keywords: corneal; tlr receptor; dpc; cd14 ... See more keywords
Blockade of an innate immune amplifier to fight immune hyperactivation in COVID-19?
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103086
Abstract: Long before reaching its peak, the SARS-CoV-2 pandemic has already met the 1 million death toll worldwide. Since whether and when an effective vaccine will be available is unknown, there is an urgent need for… read more here.
Keywords: immune; blockade innate; covid; cd14 ... See more keywords
Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.03.014
Abstract: BACKGROUND Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in… read more here.
Keywords: live dead; phagocytosis; inhibition; coli ... See more keywords
microRNA-331-3p maintains the contractile type of vascular smooth muscle cells by regulating TNF-α and CD14 in intracranial aneurysm
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107858
Abstract: Dysfunction of vascular smooth muscle cells (VSMCs) may be linked to intracranial aneurysm (IA) formation. VSMCs possess a phenotypic plasticity, capable of changing from a mature, contractile to a less differentiated, synthetic phenotype. In this… read more here.
Keywords: aneurysm; mir 331; tnf cd14; cd14 ... See more keywords
Tie2-expressing monocytes/macrophages promote cerebral revascularization in peri-infarct lesions upon ischemic insult
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00637-w
Abstract: Dear Editor, Strokes cause 5.8 million deaths each year. Among these victims, ~30% are from China. Acute ischemic stroke (AIS) is the most prevalent subtype of strokes. Although drugs can alleviate the symptoms, the recoveries… read more here.
Keywords: supplementary fig; blood; cd14; fig ... See more keywords
The significance of CD14 in clear cell renal cell carcinoma progression and survival prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2142292
Abstract: Abstract Purpose: CD14-positive tumour and immune cells have been implicated in cancer progression. This study evaluated the prognostic significance of CD14 immunostaining in clear cell renal cell carcinoma (ccRCC) compared to the adjacent non-cancer kidney,… read more here.
Keywords: cell; cd14; prognosis; kidney ... See more keywords
A Liquid Biopsy to Assess Brain Tumor Recurrence: Presence of Circulating Mo-MDSC and CD14+ VNN2+ Myeloid Cells as Biomarkers That Distinguish Brain Metastasis From Radiation Necrosis Following Stereotactic Radiosurgery.
Sign Up to like & getrecommendations! Published in 2020 at "Neurosurgery"
DOI: 10.1093/neuros/nyaa334
Abstract: BACKGROUND Brain metastases (BM) are the most common type of brain tumor malignancy in the US. They are also the most common indication for stereotactic radiosurgery (SRS). However, the incidence of both local recurrence and… read more here.
Keywords: biopsy; recurrence; brain metastasis; cd14 ... See more keywords
Prognostic value of Toll-like receptor 4 on human monocyte subsets combined with computed tomography-adapted Leaman score assessing coronary artery disease.
Sign Up to like & getrecommendations! Published in 2023 at "Coronary artery disease"
DOI: 10.1097/mca.0000000000001250
Abstract: BACKGROUND Upregulation of Toll-like receptor 4 (TLR-4) is associated with coronary plaque vulnerability assessed by coronary computed tomography angiography (CCTA). Computed tomography-adapted Leaman score (CT-LeSc) is an independent long-term predictor of cardiac events. The relationship… read more here.
Keywords: cd14 cd16; cd14; cardiac events; expression ... See more keywords
Phase 1b dose-escalation, safety, and pharmacokinetic study of IC14, a monoclonal antibody against CD14, for the treatment of amyotrophic lateral sclerosis
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DOI: 10.1097/md.0000000000027421
Abstract: Supplemental Digital Content is available in the text Abstract Background: The primary objective was to demonstrate the safety and tolerability of monoclonal antibody against CD14 (IC14) (atibuclimab) in amyotrophic lateral sclerosis patients. The secondary objectives… read more here.
Keywords: treatment; amyotrophic lateral; cd14; lateral sclerosis ... See more keywords
CD14+CD16+ monocytes are involved in daratumumab‐mediated myeloma cells killing and in anti‐CD47 therapeutic strategy
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16548
Abstract: A deep elucidation of the mechanisms of action of anti‐CD38 monoclonal antibodies (mAbs), such as daratumumab (DARA), is required to identify patients with multiple myeloma (MM) who are more responsive to this treatment. In the… read more here.
Keywords: cells killing; cd16; cd16 monocytes; cd14 cd16 ... See more keywords