CD14 is not required for carbon tetrachloride-induced hepatic inflammation and fibrosis with or without lipopolysaccharide challenge.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cellular physiology"
DOI: 10.1002/jcp.31030
Abstract: Binding of lipopolysaccharide (LPS) to CD14 is required for its cellular effects via TLR4. A role of LPS/TLR4-mediated signaling in activated hepatic stellate cells (aHSCs), the major fibrogenic cells, in liver fibrosis has been reported.… read more here.
Keywords: inflammation; cd14; cd14 required; expression ... See more keywords
Combined blockade of complement C5 and TLR co-receptor CD14 synergistically inhibits pig-to-human corneal xenograft induced innate inflammatory responses.
Sign Up to like & getrecommendations! Published in 2021 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2021.03.047
Abstract: Inadequate supplies of donor corneas have evoked an escalating interest in corneal xenotransplantation. However, innate immune responses contribute significantly to the mechanism of xenograft rejection. We hypothesized that complement component C5 and TLR co-receptor CD14… read more here.
Keywords: corneal; tlr receptor; dpc; cd14 ... See more keywords
Blockade of an innate immune amplifier to fight immune hyperactivation in COVID-19?
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.103086
Abstract: Long before reaching its peak, the SARS-CoV-2 pandemic has already met the 1 million death toll worldwide. Since whether and when an effective vaccine will be available is unknown, there is an urgent need for… read more here.
Keywords: immune; blockade innate; covid; cd14 ... See more keywords
Phagocytosis of live and dead Escherichia coli and Staphylococcus aureus in human whole blood is markedly reduced by combined inhibition of C5aR1 and CD14.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular immunology"
DOI: 10.1016/j.molimm.2019.03.014
Abstract: BACKGROUND Sepsis is a dysregulated host response to infection. The aim of this study was to investigate the effects of complement- and CD14 inhibition on phagocytosis of live and dead Gram-negative and Gram-positive bacteria in… read more here.
Keywords: live dead; phagocytosis; inhibition; coli ... See more keywords
microRNA-331-3p maintains the contractile type of vascular smooth muscle cells by regulating TNF-α and CD14 in intracranial aneurysm
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107858
Abstract: Dysfunction of vascular smooth muscle cells (VSMCs) may be linked to intracranial aneurysm (IA) formation. VSMCs possess a phenotypic plasticity, capable of changing from a mature, contractile to a less differentiated, synthetic phenotype. In this… read more here.
Keywords: aneurysm; mir 331; tnf cd14; cd14 ... See more keywords
Tie2-expressing monocytes/macrophages promote cerebral revascularization in peri-infarct lesions upon ischemic insult
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00637-w
Abstract: Dear Editor, Strokes cause 5.8 million deaths each year. Among these victims, ~30% are from China. Acute ischemic stroke (AIS) is the most prevalent subtype of strokes. Although drugs can alleviate the symptoms, the recoveries… read more here.
Keywords: supplementary fig; blood; cd14; fig ... See more keywords
Effect of spironolactone on monocyte subsets in atrial fibrillation: IMPRESS-AF randomised controlled trial
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-74592-1
Abstract: Monocyte subsets differentially influence pathophysiology of heart failure and atrial fibrillation (AF) through inflammation, fibrosis, and angiogenesis. Spironolactone has antifibrotic properties. This study investigated the effect spironolactone on monocyte subsets and monocyte effects for peak… read more here.
Keywords: effect; impress; monocyte subsets; cd14 ... See more keywords
The significance of CD14 in clear cell renal cell carcinoma progression and survival prognosis
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2142292
Abstract: Abstract Purpose: CD14-positive tumour and immune cells have been implicated in cancer progression. This study evaluated the prognostic significance of CD14 immunostaining in clear cell renal cell carcinoma (ccRCC) compared to the adjacent non-cancer kidney,… read more here.
Keywords: cell; cd14; prognosis; kidney ... See more keywords
Developing a Serum-Free and Cytokine-Optimizing Induction Medium to Increase the Production of CD14+CD16+ and CD14+CD16− Monocytes from Human CD133+ Hematopoietic Stem and Progenitor Cells
Sign Up to like & getrecommendations! Published in 2025 at "Stem Cells and Development"
DOI: 10.1089/scd.2024.0143
Abstract: Immunotherapy utilizes immune cells to target cancer and improves treatment outcomes with few side effects. Despite the effectiveness of immunotherapy, the limited availability of monocytes, which are essential for the differentiation of antigen-presenting cells, remains… read more here.
Keywords: cd14 cd16; stem; cd16 monocytes; medium ... See more keywords
#2751 CD14++CD16+ monocytes and CD8+ T cells are independently associated with annual change in eGFR and proteinuria in kidney transplant recipients
Sign Up to like & getrecommendations! Published in 2024 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfae069.990
Abstract: Immune cellular responses are implicated in all clinical aspects of kidney transplantation. There is little data regarding the additional value of regular monitoring of immune cells subsets expression in kidney transplant recipients (KTRs). The aim… read more here.
Keywords: egfr; cd8 cells; cd14 cd16; cd16 monocytes ... See more keywords
A Liquid Biopsy to Assess Brain Tumor Recurrence: Presence of Circulating Mo-MDSC and CD14+ VNN2+ Myeloid Cells as Biomarkers That Distinguish Brain Metastasis From Radiation Necrosis Following Stereotactic Radiosurgery.
Sign Up to like & getrecommendations! Published in 2020 at "Neurosurgery"
DOI: 10.1093/neuros/nyaa334
Abstract: BACKGROUND Brain metastases (BM) are the most common type of brain tumor malignancy in the US. They are also the most common indication for stereotactic radiosurgery (SRS). However, the incidence of both local recurrence and… read more here.
Keywords: biopsy; recurrence; brain metastasis; cd14 ... See more keywords