CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202103719
Abstract: The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with weight loss and… read more here.
Keywords: cd146; pro inflammatory; polarization; obesity ... See more keywords
CD146 expression in oral lichen planus and oral cancer
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02871-7
Abstract: Objective To examine the CD146/METCAM expression on keratinocytes in normal oral mucosa (NOM), oral lichen planus (OLP), oral epithelial dysplasia (OED), and oral squamous cell carcinoma (OSCC). Subjects and methods Immunohistochemical examination of CD146 was… read more here.
Keywords: lichen planus; oral lichen; cd146; olp oed ... See more keywords
CD146 positive human dental pulp stem cells promote regeneration of dentin/pulp-like structures
Sign Up to like & getrecommendations! Published in 2017 at "Human Cell"
DOI: 10.1007/s13577-017-0198-2
Abstract: CD146 and STRO-1 are endothelial biomarkers that are co-expressed on the cellular membranes of blood vessels within human dental pulp tissue. This study characterized the percentage of dentin-like structures produced by CD146-positive (CD146+) human dental… read more here.
Keywords: cd146 cells; dentin; cd146; like structures ... See more keywords
CD146 Regulates Growth Factor-Induced mTORC2 Activity Independent of the PI3K and mTORC1 Pathways.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.09.047
Abstract: The mechanistic target of rapamycin complex 2 (mTORC2) coordinates cell proliferation, survival, and metabolism with environmental inputs, yet how extracellular stimuli such as growth factors (GFs) activate mTORC2 remains enigmatic. Here we demonstrate that in… read more here.
Keywords: mtorc2 activity; cd146; mtorc1 pathways; pi3k mtorc1 ... See more keywords
Immunohistochemical Expression of MCAM/CD146 in Canine Melanoma
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Pathology"
DOI: 10.1016/j.jcpa.2017.05.001
Abstract: MCAM/CD146 (melanoma cell adhesion molecule/CD146) is a transmembrane immunoglobulin superfamily cell adhesion molecule involved in transendothelial migration and signal transduction. It is expressed in melanoma, squamous cell carcinoma, prostatic, ovarian, cervical and endometrial cancers and… read more here.
Keywords: melanoma; cd146 canine; cd146; mcam cd146 ... See more keywords
CD146 (MCAM) in human cs-DLK1-/cs-CD34+ adipose stromal/progenitor cells.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cell research"
DOI: 10.1016/j.scr.2017.05.004
Abstract: To precisely characterize CD146 in adipose stromal/progenitor cells (ASCs) we sorted the stromal vascular faction (SVF) of human abdominal subcutaneous white adipose tissue (sWAT) according to cell surface (cs) expression of CD146, DLK1 and CD34.… read more here.
Keywords: cd146; cd146 cells; dlk1 cd34; cd34 cd146 ... See more keywords
Reversing the Epithelial-Mesenchymal Transition in Metastatic Cancer Cells Using CD146-Targeted Black Phosphorus Nanosheets and a Mild Photothermal Treatment.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c11070
Abstract: Cancer metastasis leads to most deaths in cancer patients, and the epithelial-mesenchymal transition (EMT) is the key mechanism that endows the cancer cells with strong migratory and invasive abilities. Here, we present a nanomaterial-based approach… read more here.
Keywords: cancer; cd146; mild photothermal; photothermal treatment ... See more keywords
The CD146-HIF-1α axis regulates epithelial cell migration and alveolar maturation in a mouse model of bronchopulmonary dysplasia
Sign Up to like & getrecommendations! Published in 2022 at "Laboratory Investigation"
DOI: 10.1038/s41374-022-00773-z
Abstract: Bronchopulmonary dysplasia (BPD) is the most common challenge in preterm neonates. Retardation of alveolar development characterizes the pulmonary pathology in BPD. In the present study, we explored the roles of the CD146-HIF-1α axis in BPD.… read more here.
Keywords: hif axis; cd146 hif; bpd; cd146 ... See more keywords
NMR-based insight into galectin-3 binding to endothelial cell adhesion molecule CD146: evidence for non-canonical interactions with the lectin's CRD β-sandwich F-face.
Sign Up to like & getrecommendations! Published in 2019 at "Glycobiology"
DOI: 10.1093/glycob/cwz036
Abstract: Galectin-3 (Gal-3) binds to cell adhesion glycoprotein CD146 to promote cytokine secretion and mediate endothelial cell migration. Here, we used NMR 15N-HSQC spectroscopy to investigate binding between 15N-labeled Gal-3 and the extracellular domain (eFL) of… read more here.
Keywords: cd146; endothelial cell; cell adhesion; lectin crd ... See more keywords
STEM-11. CD146/MCAM REGULATES MESENCHYMAL PROPERTIES, STEMNESS, RADIO-RESISTANCE AND YAP ACTIVITY IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.985
Abstract: Glioblastoma (GBM), a highly malignant and lethal brain tumor, is characterized by diffuse invasion into the brain and chemoradiotherapy resistance resulting in recurrences and poor prognosis. In this study we examined if the cell adhesion… read more here.
Keywords: cell; cd146; resistance; expression ... See more keywords
Prospective Isolation and Characterization of Chondroprogenitors from Human Chondrocytes Based on CD166/CD34/CD146 Surface Markers.
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DOI: 10.1177/19476035211042412
Abstract: PURPOSE Chondrocytes, isolated from articular cartilage, are routinely utilized in cell-based therapeutics for the treatment of cartilage pathologies. However, restoration of the biological tissue faces hindrance due to the formation of primarily fibrocartilaginous repair tissue.… read more here.
Keywords: cd34; cd146; cd166 cd146; cd166 cd34 ... See more keywords