Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001258
Abstract: Background Anti-CD154 monotherapy is associated with antidonor allo-antibody (Ab) elaboration, cardiac allograft vasculopathy (CAV), and allograft failure in preclinical primate cell and organ transplant models. In the context of calcineurin inhibitors (CNI), these pathogenic phenomena… read more here.
Keywords: agr cd154; allograft; cd154; cd20 ... See more keywords
AB0055 Hydroxychloroquine inhibits soluble cd154 production through ca2+ and pkc signalling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.3172
Abstract: Background: Over-expression of membranous CD154 and soluble CD154 (sCD154) in T lymphocytes is important in pathogenesis of autoimmune diseases. PKC pathway induces sCD154 production through promoting shedding of membranous CD154. Objectives: Hydroxychloroquine (HCQ) has been… read more here.
Keywords: production; pkc signalling; cd154; signalling pathway ... See more keywords
A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation
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DOI: 10.1155/2017/2982879
Abstract: Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key… read more here.
Keywords: granulomatous inflammation; inflammation role; inflammation; cd40 ... See more keywords
Tumor necrosis factor-α blockade treatment decreased CD154 (CD40-ligand) expression in rheumatoid arthritis
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DOI: 10.1371/journal.pone.0183726
Abstract: Contexts CD154 (commonly referred to as CD40-ligand) is a critical T cell factor that participates in the pathogenesis of autoimmune and is over-expressed in rheumatoid arthritis (RA). TNF-α blockade treatment had dramatic efficacy in RA.… read more here.
Keywords: tnf blockade; treatment; cd154; expression ... See more keywords