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   Articles with "cd154" as a keyword



Mechanisms of donor-specific transfusion synergy with anti-CD154 for transplant acceptance.

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recommendations! Published in 2025 at "Journal of immunology"

DOI: 10.1093/jimmun/vkaf320

Abstract: Organ transplantation is a life-saving treatment for patients with end-stage organ failure but requires lifelong immunosuppression that can result in significant complications. Achieving stable and durable donor-specific tolerance, whereby immunosuppression can be stopped without precipitating… read more here.

Keywords: anti cd154; donor specific; dst; cd154 ... See more keywords

Preemptive CD20+ B cell Depletion Attenuates Cardiac Allograft Vasculopathy in CD154-Treated Monkeys

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recommendations! Published in 2017 at "Transplantation"

DOI: 10.1097/tp.0000000000001258

Abstract: Background Anti-CD154 monotherapy is associated with antidonor allo-antibody (Ab) elaboration, cardiac allograft vasculopathy (CAV), and allograft failure in preclinical primate cell and organ transplant models. In the context of calcineurin inhibitors (CNI), these pathogenic phenomena… read more here.

Keywords: agr cd154; allograft; cd154; cd20 ... See more keywords

AB0055 Hydroxychloroquine inhibits soluble cd154 production through ca2+ and pkc signalling pathway

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recommendations! Published in 2018 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/annrheumdis-2018-eular.3172

Abstract: Background: Over-expression of membranous CD154 and soluble CD154 (sCD154) in T lymphocytes is important in pathogenesis of autoimmune diseases. PKC pathway induces sCD154 production through promoting shedding of membranous CD154. Objectives: Hydroxychloroquine (HCQ) has been… read more here.

Keywords: production; pkc signalling; cd154; signalling pathway ... See more keywords

A Role for CD154, the CD40 Ligand, in Granulomatous Inflammation

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recommendations! Published in 2017 at "Mediators of Inflammation"

DOI: 10.1155/2017/2982879

Abstract: Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key… read more here.

Keywords: granulomatous inflammation; inflammation role; inflammation; cd40 ... See more keywords

Tumor necrosis factor-α blockade treatment decreased CD154 (CD40-ligand) expression in rheumatoid arthritis

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recommendations! Published in 2017 at "PLoS ONE"

DOI: 10.1371/journal.pone.0183726

Abstract: Contexts CD154 (commonly referred to as CD40-ligand) is a critical T cell factor that participates in the pathogenesis of autoimmune and is over-expressed in rheumatoid arthritis (RA). TNF-α blockade treatment had dramatic efficacy in RA.… read more here.

Keywords: tnf blockade; treatment; cd154; expression ... See more keywords