Abstract 6172: PI3K/Akt signaling pathway regulates CD155 expression involved in resistance to cancer immunotherapy
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DOI: 10.1158/1538-7445.am2025-6172
Abstract: Although anti-programmed death 1 (PD-1)/PD-1 ligand 1 monoclonal antibodies are effective against various cancers, resistance remains a significant issue in many patients. The immunosuppressive T cell immunoreceptor with Ig and ITIM domains (TIGIT)/CD155 axis has… read more here.
Keywords: resistance; akt signaling; expression; signaling pathway ... See more keywords
Overexpression of CD155 is associated with PD-1 and PD-L1 expression on immune cells, rather than tumor cells in the breast cancer microenvironment
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DOI: 10.12998/wjcc.v8.i23.5935
Abstract: BACKGROUND CD155 is an immune checkpoint protein in cancers and interacts with ligands to regulate the immune microenvironment. The expression of CD155 is correlated with the prognosis and pathological features of breast cancer. AIM To… read more here.
Keywords: cd155 expression; cd155; breast cancer; expression ... See more keywords
Clinical significance of CD155 expression and correlation with immune cell infiltration in triple-negative breast cancer
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DOI: 10.21037/tcr-2025-643
Abstract: Background As a newly focused immune checkpoint protein in cancers, CD155 is a potential target in immunotherapy. Tumor microenvironment (TME) as a crucial regulatory factor in immunotherapy, also plays a significant role in the development… read more here.
Keywords: cd155; infiltration; lymph node; expression ... See more keywords
Prognostic and Predictive Significance of B7-H3 and CD155 Expression in Gastric Cancer Patients
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DOI: 10.3390/diagnostics15212695
Abstract: Background/Objectives: This study aimed to characterize the expression patterns of B7 homolog 3 (B7-H3) and cluster of differentiation 155 (CD155), two immune-related transmembrane glycoproteins, in resectable gastric adenocarcinoma and to elucidate their clinicopathological, prognostic, and… read more here.
Keywords: stage; invasion; cd155; expression ... See more keywords
CD155 expression and its clinical significance in non-small cell lung cancer
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DOI: 10.3892/ol.2022.13286
Abstract: CD155 serves an important role in tumor progression by promoting cell proliferation and migration. CD155 is also involved in the immune evasion of tumor cells, which may cause the development and progression of tumors. Accordingly,… read more here.
Keywords: cd155 expression; expression; lung; tumor ... See more keywords
CD155 immunohistochemical expression in upper tract urothelial carcinoma predicts poor prognosis.
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DOI: 10.3892/ol.2022.13534
Abstract: A novel immune checkpoint, CD155/T-cell immunoreceptor with Ig and ITIM domains, has been recognized as a new therapeutic target in addition to conventional immune checkpoints, such as anti-programmed cell death protein 1/programmed cell death ligand… read more here.
Keywords: cd155 expression; immunohistochemical expression; expression; urothelial carcinoma ... See more keywords