CD169 + sinus macrophages in regional lymph nodes do not predict mismatch‐repair status of patients with colorectal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5747
Abstract: Mismatch‐repair deficiency and microsatellite instability‐high (dMMR/MSI‐H) colorectal cancer (CRC) is treated with programmed death (PD)‐1 antibody regardless of PD‐ligand (L)1 expression in tumor cells. We previously found that abundant CD169+ macrophages in regional lymph node… read more here.
Keywords: mismatch repair; regional lymph; colorectal cancer; cd169 ... See more keywords
CD169+ macrophages in lymph node and spleen critically depend on dual RANK and LTbetaR signaling
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108540119
Abstract: Significance The CD169+ macrophages that play an important role in the fight against infections and cancer are receptive to environmental signals for their differentiation. We show that lymph node and splenic CD169+ macrophages require both… read more here.
Keywords: cd169; lymph node; cd169 macrophages; node spleen ... See more keywords
Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1985857
Abstract: The study aimed to evaluate the prognostic value of CD169 expression in tumor-infiltrating macrophages from regional lymph nodes(RLN) in various tumors. In order to identify eligible articles, PubMed, EMBASE, Web of Science, and Cochrane Library… read more here.
Keywords: various tumors; cd169; cd169 expression; prognostic value ... See more keywords
Abstract 17501: Splenic CD169 + Tim4 + Marginal Zone Metallophilic Macrophages Are Essential for Wound Healing and Resolution of Inflammation After Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.17501
Abstract: Fidelity of wound healing after myocardial infarction (MI) is an important determinant of subsequent adverse cardiac remodeling and failure. Infiltrating Ly6C hi blood monocytes are a key component of this healing response; however, the importance… read more here.
Keywords: wound healing; cd169 tim4; splenic cd169; marginal zone ... See more keywords
CD169-CD43 interaction is involved in erythroblastic island formation and erythroid differentiation.
Sign Up to like & getrecommendations! Published in 2023 at "Haematologica"
DOI: 10.3324/haematol.2022.282192
Abstract: CD169, a specific marker for macrophages, is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family which acts as an adhesion molecule implicated in cell-cell interaction via sialylated glycoconjugates. Although CD169+ macrophages have been… read more here.
Keywords: erythroid differentiation; cd43; ebi formation; cd169 ... See more keywords
CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.919097
Abstract: Immunotherapy is a promising therapeutic area in cancer and chronic viral infections. An important component of immunotherapy in these contexts is the activation of innate immunity. Here we investigate the potential for CD169 (Siglec 1)… read more here.
Keywords: toll like; biomarker; immunotherapy; like receptor ... See more keywords
CD169+ Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02472
Abstract: Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there has been an ongoing debate to what extent macrophages and DCs are related and perform different functions. The current view… read more here.
Keywords: cd169; macrophages dcs; immune responses; cd169 macrophages ... See more keywords
CD169 Expression on Lymph Node Macrophages Predicts in Patients With Gastric Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.636751
Abstract: The induction of an anti-cancer immune responses is potentially associated with the efficacy of anti-cancer therapy. Recent studies have indicated that sinus macrophages in regional lymph nodes are involved in anti-cancer immune responses in the… read more here.
Keywords: cd169; gastric cancer; lymph; expression ... See more keywords
CD169+ Macrophages in Primary Breast Tumors Associate with Tertiary Lymphoid Structures, Tregs and a Worse Prognosis for Patients with Advanced Breast Cancer
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DOI: 10.3390/cancers15041262
Abstract: Simple Summary We here show that CD169+ TAMs in primary breast tumors are associated with tertiary lymphoid-like structures (TLLSs), Treg and Breg signatures, and a worse prognosis for the patient. In contrast, CD169+ TAMs and… read more here.
Keywords: prognosis; breast; breast tumors; cd169 ... See more keywords
CD169+ Monocyte and Regulatory T Cell Subsets Are Associated with Disease Activity in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12111875
Abstract: Disease activity in rheumatoid arthritis (RA) is influenced by activation of circulating and synovial immune cells. Regulatory T cells (Tregs) and monocytes are key cells that drive inflammation in RA. This study investigated if a… read more here.
Keywords: monocyte; disease; disease activity; cd169 ... See more keywords