Allotype-specific processing of the CD16a N45-glycan from primary human natural killer cells and monocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Glycobiology"
DOI: 10.1093/glycob/cwaa002
Abstract: Fc γ receptor IIIa/CD16a is an activating cell surface receptor with a well-defined role in NK cell and monocyte effector function. The extracellular domain is decorated with five asparagine (N)-linked glycans; N-glycans at N162 and… read more here.
Keywords: cd16a; natural killer; human natural; primary human ... See more keywords
Inhibiting N-glycan processing increases the antibody binding affinity and effector function of human natural killer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Immunology"
DOI: 10.1111/imm.13662
Abstract: Novel approaches are required to improve the efficacy of immunotherapies and increase the proportion of patients who experience a benefit. Antibody-dependent cell-mediated cytotoxicity (ADCC) contributes to the efficacy of many monoclonal antibodies therapies. Natural killer… read more here.
Keywords: cell; antibody binding; cd16a; glycan processing ... See more keywords
Abstract 4556: Preclinical pharmacology and safety of RO7297089, a novel anti-BCMA/CD16a bispecific antibody for the treatment of multiple myeloma
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-4556
Abstract: RO7297089 is a bispecific antibody (IgG-scFv) targeting Bcell maturation antigen (BCMA) and CD16a (FcγRIIIA) that is being developed for the treatment of multiple myeloma (MM). BCMA is exclusively expressed on plasmablasts and differentiated plasma cells… read more here.
Keywords: ro7297089; treatment; bcma; cd16a ... See more keywords
Abstract B57: Effect of ADAM17 inhibition on the release of IFN-y during natural killer cell-mediated antibody dependent cellular cytotoxicity in cancer
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DOI: 10.1158/2326-6074.tumimm17-b57
Abstract: Introduction: Antibody-dependent cell cytotoxicity (ADCC) by NK cells is a key mechanism in the anti-cancer effects of therapeutic antibodies. CD16a is an IgG Fc receptor (FcRIII) present on the surface of NK cells and plays… read more here.
Keywords: adam17; cd16a; antibody; cancer ... See more keywords
Examination of IgG Fc Receptor CD16A and CD64 Expression by Canine Leukocytes and Their ADCC Activity in Engineered NK Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.841859
Abstract: Human natural killer (NK) cells can target tumor cells in an antigen-specific manner by the recognition of cell bound antibodies. This process induces antibody-dependent cell-mediated cytotoxicity (ADCC) and is exclusively mediated by the low affinity… read more here.
Keywords: canine cd16a; canine; expression; cd16a cd64 ... See more keywords