C3-CD18-VATPase-ATG16L1 and C3-ATG16L1 axes restrict the escape of microbes through the autophagy-lysosome pathway.
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DOI: 10.1093/jimmun/vkaf290
Abstract: As the key component of the complement system, C3 plays important roles in complement activation to regulate phagocytosis, lyse cells, mediate inflammation, and clear immune complexes. In the present study, CgC3 in the cell-free hemolymph… read more here.
Keywords: lysosome pathway; atg16l1; autophagy lysosome; cd18 ... See more keywords
Leukocyte Adhesion Deficiency-I (LAD-I): A Comprehensive Review of Published Cases
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DOI: 10.1182/blood.v130.suppl_1.4821.4821
Abstract: LAD-I is a rare disorder of leukocyte adhesion, resulting from ITGB2 gene mutations encoding for the Beta-2 Integrin component CD18. CD18 deficiencies prevent integrin dimerization and endothelial leukocyte adhesion, essential for extravasation and antimicrobial activity.… read more here.
Keywords: lad; cd18; hsct; leukocyte adhesion ... See more keywords
CD18 Mediates Neutrophil Imperviousness to the Aggregatibacter actinomycetemcomitans JP2 Clone in Molar-Incisor Pattern Periodontitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.847372
Abstract: Introduction Molar-incisor pattern periodontitis (MIPP) in the absence of significant local risk factors or systemic disease, is a rare, early onset periodontal disease phenotype, with 0.5% to 2.5% global prevalence. The condition is characterized by… read more here.
Keywords: jp2; cd18; mipp; periodontally healthy ... See more keywords