LAUSR: cd19 cd20

Intein-based modular chimeric antigen receptor platform for specific CD19/CD20 co-targeting.

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0 Published in 2025 at "Molecular oncology"

DOI: 10.1002/1878-0261.70146

Abstract: Development of chimeric antigen receptor T-cell therapy has revolutionized the treatment of B-cell malignancies, although challenges such as antigen escape and tumor heterogeneity often decrease treatment success. Modular CARs targeting multiple antigens have been proposed… read more here.

Keywords: antigen; chimeric antigen; cd19 cd20; antigen receptor ... See more keywords

CD19/CD20‐REDIRECTED BISPECIFIC CAR T CELL TREATMENT IN PATIENTS WITH RELAPSED OR REFRACTORY B‐CELL NON‐HODGKIN LYMPHOMA

Patients with systemic lupus erythematosus show increased proportions of CD19+CD20− B cells and secretion of related autoantibodies

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1 Published in 2020 at "Clinical Rheumatology"

DOI: 10.1007/s10067-020-05220-2

Abstract: Background At present, anti-CD20 monoclonal antibody treatments targeting systemic lupus erythematosus (SLE) are complex, variable, and often have disappointing outcomes. High levels of programmed cell death-1 (PD-1) and its ligands (PD-L1, PD-L2) or CD80/CD86 on… read more here.

Keywords: cd20 cells; sle patients; cd19 cd20; systemic lupus ... See more keywords

P167 Overcoming rituximab resistance in autoimmune disease: back to basics

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2 Published in 2023 at "Rheumatology"

DOI: 10.1093/rheumatology/kead104.208

Abstract: Previous research into B cell biomarkers of poor response to the anti-CD20 drug rituximab in autoimmune disease relates to insufficient B cell depletion. Expansion of memory B cell (MBC) subsets were also associated with poorer… read more here.

Keywords: autoimmune disease; cd19 cd20; none; rituximab ... See more keywords

OP0356 Plasmablast proliferation is associated with toll like receptor 7 polymorphisms and upregulation of type i interferon, contributing to the antibody production in antiphospholipid syndrome

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0 Published in 2018 at "Annals of the Rheumatic Diseases"

DOI: 10.1136/annrheumdis-2018-eular.2816

Abstract: Background Antiphospholipid antibodies (aPL) as pathogenic autoantibodies in systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) are supported by a number of clinical, ex vivo and animal studies. Nevertheless, aPL are not eliminated by corticosteroid… read more here.

Keywords: toll like; antiphospholipid syndrome; aps patients; production ... See more keywords

Development of a compact bidirectional promoter-driven dual chimeric antigen receptor (CAR) construct targeting CD19 and CD20 in the Sleeping Beauty (SB) transposon system

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0 Published in 2024 at "Journal for ImmunoTherapy of Cancer"

DOI: 10.1136/jitc-2023-008555

Abstract: Background A bidirectional promoter-driven chimeric antigen receptor (CAR) cassette provides the simultaneous expression of two CARs, which significantly enhances dual antigen-targeted CAR T-cell therapy. Methods We developed a second-generation CAR directing CD19 and CD20 antigens,… read more here.

Keywords: promoter driven; bidirectional promoter; promoter; cd19 cd20 ... See more keywords

Abstract CT007: CD19/CD20 bispecific chimeric antigen receptor (CAR) in naive/memory T-cells for the treatment of relapsed or refractory B-cell lymphomas

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1 Published in 2021 at "Clinical Trials"

DOI: 10.1158/1538-7445.am2021-ct007

Abstract: 50% of patients with relapsed/refractory (R/R) B-cell lymphomas (BCL) who initially respond to CD19 CAR T therapy will relapse either due to poor CAR-T persistence or CD19 antigen escape. Preclinical data demonstrate that engineering of… read more here.

Keywords: cd19 cd20; car; cell; bispecific ... See more keywords

Comparative Assessment of Surface CD19 and CD20 Expression on B-Cell Lymphomas from Clinical Biopsies: Implications for Targeted Therapies

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1 Published in 2019 at "Blood"

DOI: 10.1182/blood-2019-129600

Abstract: Background: CD19 and CD20 are B-cell lineage-specific antigens expressed on the cell surface of most B-cell lymphomas. While CD20 is acquired during late stages of B-cell lymphogenesis and is then lost upon differentiation into plasma… read more here.

Keywords: cd19 cd20; expression; cd20; cell ... See more keywords

Preclinical Study of a Novel Tri-Specific Anti-CD3/CD19/CD20 T Cell-Engaging Antibody As a Potentially Better Treatment for NHL

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1 Published in 2020 at "Blood"

DOI: 10.1182/blood-2020-140154

Abstract: CD20 targeted therapy by means of anti-CD20 mAb is currently the most important regimen for treating B cells malignancies. However, 1-2% of B-cell lymphoma patients test negative for CD20. Besides, it has been reported in… read more here.

Keywords: cd3; cd19 cd20; cd20; cell ... See more keywords

Developing and Characterizing the Anti-Tumor Efficacy of a Tri-Specific CAR T Cell Targeting CD19, CD20 and CD22

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0 Published in 2024 at "Blood"

DOI: 10.1182/blood-2024-199366

Abstract: Chimeric antigen receptor (CAR) T cell therapy targeting proteins such as CD19 and BCMA has achieved considerable success in treating B cell cancers with several multicenter clinical trials reporting an overall response rate greater than… read more here.

Keywords: cd19 cd20; car; cell; tumor ... See more keywords

Preliminary safety and efficacy of anti-CD19/CD20 bispecific CAR-T cell therapy (JWCAR201) in patients with relapsed or refractory B-cell non-Hodgkin lymphoma: Results from an ongoing phase I study

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0 Published in 2025 at "Blood"

DOI: 10.1182/blood-2025-6088

Abstract: Background Relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) represents a significant therapeutic challenge, with historical overall response rates of 26-35% to salvage regimens and median overall survival of 6-10 months. While CD19-directed CAR-T… read more here.

Keywords: therapy; cd19 cd20; efficacy; car ... See more keywords

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