Humanized CD19‐targeted chimeric antigen receptor T (CAR‐T) cells for relapsed/refractory pediatric acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26123
Abstract: Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. 9. Palumbo A, Bringhen S, Kumar SK, et al. Second primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a metaanalysis of individual patient… read more here.
Keywords: myeloma; targeted chimeric; cd19 targeted; multiple myeloma ... See more keywords
Parallel comparison of 4-1BB or CD28 co-stimulated CD19-targeted chimeric antigen receptor-T cells for B-cell non-Hodgkin lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz253.011
Abstract: Abstract Background CD19-targeted chimeric antigen receptor-T (CAR-T) cells with CD28 or 4-1BB (28z CAR-T and BBz CAR-T) have shown great promise to treat relapsed or refractory (r/r) B cell acute lymphoblastic leukemia (B-ALL) and B… read more here.
Keywords: targeted chimeric; bbz car; cd19 targeted; car ... See more keywords
Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aav1648
Abstract: CD19-targeted CAR T cells show sustained CD19+ B cell depletion and profound therapeutic benefit in ameliorating disease in mouse models of lupus. CAR T cells: Not just for cancer CD19-targeted chimeric antigen receptor (CAR) T… read more here.
Keywords: cd19; targeted car; cd19 targeted; car cells ... See more keywords
CRLF2-rearranged B-cell ALL with extramedullary lineage switch to AML following CD19-targeted therapy
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-009499
Abstract: Lineage switch (LS) refers to the immunophenotypic transformation of one leukemia lineage to another (ie, lymphoid to myeloid) with retention of baseline genetics. This phenomenon was originally observed in infants with B-lymphoblastic leukemia (B-ALL) with… read more here.
Keywords: crlf2 rearranged; lineage; targeted therapy; following cd19 ... See more keywords
Co-infusion of high-dose haploidentical donor cells and CD19-targeted CART cells achieves complete remission, successful donor engraftment and significant CART amplification in advanced ALL
Sign Up to like & getrecommendations! Published in 2020 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758835920927605
Abstract: Autologous CD19-targeted chimeric antigen receptor-modified T cells (CD19-CART) remarkably improved the outcome of patients with advanced B-cell acute lymphoblastic leukemia (B-ALL). However, the application and outcomes of allogeneic CART cells is still uncertain. Two patients… read more here.
Keywords: cart cells; cd19 targeted; high dose; donor ... See more keywords
shRNA-based PD-1 suppression preserves memory phenotype and function of CD19-targeted CAR-T cell
Sign Up to like & getrecommendations! Published in 2025 at "Translational Cancer Research"
DOI: 10.21037/tcr-2025-938
Abstract: Background Chimeric antigen receptor T cell (CAR-T) therapy targeting cluster of differentiation 19 (CD19) has shown promise in treating B-cell acute lymphoblastic leukemia (B-ALL), but the long-term efficacy of CD19-targeted CAR-T therapy remains limited. Programmed… read more here.
Keywords: memory; car cell; car; cell ... See more keywords
Autologous CD19-Targeted Chimeric Antigen Receptor (CAR)T-Cells as the Future of Systemic Lupus Erythematosus Treatment.
Sign Up to like & getrecommendations! Published in 2023 at "Current rheumatology reviews"
DOI: 10.2174/1573397119666230214103044
Abstract: Systemic lupus erythematosus (SLE) is a chronic autoimmune illness with an unclear etiology and a range of clinical manifestations. The therapeutic results of current conventional treatments are frequently unsatisfactory. Many B-cell-directed immunotherapies have recently been… read more here.
Keywords: cd19 targeted; car; systemic lupus; treatment ... See more keywords
CD19-Targeted Immunotherapies for Diffuse Large B-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.837457
Abstract: Surgical resection, chemotherapy and radiotherapy were, for many years, the only available cancer treatments. Recently, the use of immune checkpoint inhibitors and adoptive cell therapies has emerged as promising alternative. These cancer immunotherapies are aimed… read more here.
Keywords: cell; cd19 targeted; cell lymphoma; large cell ... See more keywords
CD19 -targeted CAR T therapy treating hematologic malignancies: hidden danger is the next neighbor to security?
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1490491
Abstract: CD19-targeted chimeric antigen receptor (CAR) T-cell therapy has achieved marvelous results in the treatment of patients with relapsed and/or refractory B-cell lymphomas, B-cell acute lymphoblastic leukemia, and multiple myeloma. As a new treatment method that… read more here.
Keywords: therapy; hematologic malignancies; targeted car; car ... See more keywords