Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia
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DOI: 10.1038/s41467-021-25223-0
Abstract: Acute leukemia relapsing after chemotherapy plus allogeneic hematopoietic stem cell transplantation can be treated with donor-derived T cells, but this is hampered by the need for donor/recipient MHC-matching and often results in graft-versus-host disease, prompting… read more here.
Keywords: donor unrestricted; cd1c; specific tcr; leukemia ... See more keywords
T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids
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DOI: 10.1038/s41590-018-0065-7
Abstract: The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-recognition of a major histocompatibility complex molecule and its carried peptide. However, the molecular basis of the interactions of TCRs with… read more here.
Keywords: cell autoreactivity; autoreactivity; self lipids; cd1c ... See more keywords
NLRC4-mediated activation of CD1c+ DC contributes to perpetuation of synovitis in rheumatoid arthritis
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DOI: 10.1172/jci.insight.152886
Abstract: The individual contribution of specific myeloid subsets such as CD1c+ conventional DC (cDC) to perpetuation of rheumatoid arthritis (RA) pathology remains unclear. In addition, the specific innate sensors driving pathogenic activation of CD1c+ cDC in… read more here.
Keywords: rheumatoid arthritis; cd1c cdc; activation cd1c; cd1c ... See more keywords