Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-04461-7
Abstract: Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that… read more here.
Keywords: analogues probe; cd1d; galactosylsphingamides new; probe pocket ... See more keywords
Blocking the innate immune CD1d/NKT cell axis prevents the development of cortical hyperexcitability and posttraumatic epilepsy
Sign Up to like & getrecommendations! Published in 2025 at "Epilepsia"
DOI: 10.1111/epi.18332
Abstract: Posttraumatic epilepsy (PTE) that develops after a traumatic brain injury (TBI) cannot be prevented by current treatments. Although neuroinflammation is involved in epileptogenesis, a potential role for cellular immunity in this process is largely unknown.… read more here.
Keywords: posttraumatic epilepsy; cd1d nkt; cd1d; nkt cell ... See more keywords
The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading.
Sign Up to like & getrecommendations! Published in 2019 at "Wellcome open research"
DOI: 10.12688/wellcomeopenres.15368.1
Abstract: Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules. The hydrophobic lipid antigens are embedded in membranes… read more here.
Keywords: cd1 molecules; cd1d; sapb; antigen ... See more keywords
Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.897873
Abstract: CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens. CD1d surveys different cellular compartments including the… read more here.
Keywords: bound lipids; cd1d; class; endolysosomal pathway ... See more keywords
3D structures inferred from cDNA clones identify the CD1D-Restricted γδ T cell receptor in dromedaries
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.928860
Abstract: The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG)… read more here.
Keywords: cd1d; trd; trg; cell receptor ... See more keywords
Three-Dimensional Modeling of Camelus dromedarius T Cell Receptor Gamma (TRG)_Delta (TRD)/CD1D Complex Reveals Different Binding Interactions Depending on the TRD CDR3 Length
Sign Up to like & getrecommendations! Published in 2025 at "Antibodies"
DOI: 10.3390/antib14020046
Abstract: Background: In the adaptive immune response of the dromedary (Camelus dromedarius, Camdro), the T cell receptor (TR) repertoire of the gamma–delta (γδ) T cells is unusually diversified both by somatic hypermutation in rearranged TR gamma… read more here.
Keywords: delta; binding interactions; cd1d; trd ... See more keywords