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   Articles with "cd1d" as a keyword



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Galactosylsphingamides: new α-GalCer analogues to probe the F’-pocket of CD1d

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/s41598-017-04461-7

Abstract: Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic α-galactosylceramide, they produce a vast amount of cytokines. Here we present a synthesis that… read more here.

Keywords: analogues probe; cd1d; galactosylsphingamides new; probe pocket ... See more keywords
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The lipid transfer protein Saposin B does not directly bind CD1d for lipid antigen loading.

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recommendations! Published in 2019 at "Wellcome open research"

DOI: 10.12688/wellcomeopenres.15368.1

Abstract: Background: Lipid antigens are presented on the surface of cells by the CD1 family of glycoproteins, which have structural and functional similarity to MHC class I molecules. The hydrophobic lipid antigens are embedded in membranes… read more here.

Keywords: cd1 molecules; cd1d; sapb; antigen ... See more keywords
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Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.897873

Abstract: CD1d is an atypical MHC class I molecule which binds endogenous and exogenous lipids and can activate natural killer T (NKT) cells through the presentation of lipid antigens. CD1d surveys different cellular compartments including the… read more here.

Keywords: bound lipids; cd1d; class; endolysosomal pathway ... See more keywords
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3D structures inferred from cDNA clones identify the CD1D-Restricted γδ T cell receptor in dromedaries

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.928860

Abstract: The Camelidae species occupy an important immunological niche within the humoral as well as cell mediated immune response. Although recent studies have highlighted that the somatic hypermutation (SHM) shapes the T cell receptor gamma (TRG)… read more here.

Keywords: cd1d; trd; trg; cell receptor ... See more keywords