Simultaneous determination of mitotane, its metabolite and 5 steroid hormones in urine samples by capillary electrophoresis using β-CD2 SDS1 complexes as hydrophobic compounds solubilizers.
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DOI: 10.1002/elps.202100250
Abstract: Mitotane is a cytotoxic drug used in the treatment of inoperable adrenocortical carcinoma (ACC), it inhibits steroidogenesis as well, and therefore monitoring the level of steroid hormones in patients treated with mitotane is a crucial… read more here.
Keywords: simultaneous determination; mitotane; cd2 sds1; steroid hormones ... See more keywords