Proinflammatory CD20+ T Cells are Differentially Affected by Multiple Sclerosis Therapeutics
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Neurology"
DOI: 10.1002/ana.26216
Abstract: The frequency of CD20+ T cells was reported to be increased in several inflammatory conditions. We report that in patients with multiple sclerosis (MS), CD20+ T cells display a distinct proinflammatory phenotype with pathogenic properties.… read more here.
Keywords: proinflammatory cd20; cells differentially; cd20 cells; multiple sclerosis ... See more keywords
Phase II trial of co‐administration of CD19‐ and CD20‐targeted chimeric antigen receptor T cells for relapsed and refractory diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3259
Abstract: Abstract Purpose Anti‐CD19 chimeric antigen receptor T (CAR‐T) cell therapy has demonstrated remarkable efficacy for refractory and relapsed diffuse large B cell lymphoma (R/R DLBCL). However, this therapy failed in nearly 25% patients mainly due… read more here.
Keywords: cd19; anti cd19; antigen; cd20 ... See more keywords
18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4214-x
Abstract: PurposeMetabolic imaging using [18F]FDG is the current standard for clinical PET; however, some malignancies (e.g., indolent lymphomas) show low avidity for FDG. The majority of B cell lymphomas express CD20, making it a valuable target… read more here.
Keywords: pet; cell; transgenic mice; cd20 ... See more keywords
An immunosuppressive macrophage profile attenuates the prognostic impact of CD20-positive B cells in human soft tissue sarcoma
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02322-y
Abstract: BackgroundImmune cells can regulate disease progression and response to treatment in multiple tumor types, but their activities in human soft tissue sarcoma are poorly characterized.MethodsMarker-defined immune cell subsets were characterized from a tumor microenvironmental perspective in… read more here.
Keywords: tissue sarcoma; soft tissue; human soft; tissue ... See more keywords
The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome
Sign Up to like & getrecommendations! Published in 2018 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-018-4834-7
Abstract: PurposeThe purpose of the study was to evaluate protein expression of PD-L1 and CD20 as prognostic biomarkers of patient outcome in inflammatory breast cancer (IBC) samples.MethodsPD-L1 and CD20 protein expression was measured by immunohistochemistry in… read more here.
Keywords: cd20 tils; breast cancer; ibc; cd20 ... See more keywords
Dietary Spirulina platensis phycocyanin improves growth, tissue histoarchitecture, and immune responses, with modulating immunoexpression of CD3 and CD20 in Nile tilapia, Oreochromis niloticus
Sign Up to like & getrecommendations! Published in 2022 at "Aquaculture"
DOI: 10.1016/j.aquaculture.2021.737413
Abstract: Abstract This experiment was performed to examine the impact of dietary Spirulina platensis phycocyanin (SPC) on the growth performance, antioxidant status, histomorphology of certain organs, immune status with analyzing the immunohistochemical expression of CD3 and… read more here.
Keywords: cd3; growth; cd20; spc supplementation ... See more keywords
Depletion of CD20 B cells fails to inhibit relapsing mouse experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2017 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2017.03.013
Abstract: BACKGROUND Multiple sclerosis (MS) is often considered to be a CD4, T cell-mediated disease. This is largely based on the capacity of CD4 T cells to induce relapsing experimental autoimmune encephalomyelitis (EAE) in rodents. However,… read more here.
Keywords: cell depletion; autoimmune encephalomyelitis; depletion; cd20 ... See more keywords
Recall response to COVID-19 antigen is preserved in people with multiple sclerosis on anti-CD20 medications – A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Multiple Sclerosis and Related Disorders"
DOI: 10.1016/j.msard.2022.103560
Abstract: Background Antibody responses to SARS-CoV-2 vaccination are impaired in people with multiple sclerosis (MS) under anti-CD20 therapies. It is however unclear, whether patients who received the basic immunization prior to anti-B cell medication start respond… read more here.
Keywords: vaccine cohort; cd20 vaccine; antibody; anti cd20 ... See more keywords
Association between nonspecific interstitial pneumonia and presence of CD20+ B lymphocytes within pulmonary lymphoid follicles
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DOI: 10.1038/s41598-017-17208-1
Abstract: Nonspecific interstitial pneumonia (NSIP) is characterised by interstitial infiltration of lymphocytes and varying amounts of interstitial fibrosis. B cells have been suggested to contribute to the pathogenesis of NSIP. However, the relationship between B-lymphocyte and… read more here.
Keywords: cd20 lymphocytes; lymphoid follicles; nonspecific interstitial; follicular cd20 ... See more keywords
Induction of potent apoptosis by an anti-CD20 aptamer via the crosslink of membrane CD20 on non-Hodgkin's lymphoma cells
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c6ra27154e
Abstract: Targeted therapy opened a new era for the treatment of malignancies. Recently, there is growing interest in the development of novel targeted ligands except for monoclonal antibodies (mAbs). Aptamers are a class of therapeutic oligonucleotides… read more here.
Keywords: hodgkin lymphoma; via crosslink; non hodgkin; anti cd20 ... See more keywords
B cells reappear less mature and more activated after their anti-CD20–mediated depletion in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2012249117
Abstract: Significance Anti-CD20–mediated B cell depletion is a highly effective therapy in MS. However, long-term effects of this approach on the immune system are not yet characterized in detail. After cessation of anti-CD20 treatment, B cells… read more here.
Keywords: treatment; cd20 mediated; anti cd20; depletion ... See more keywords