Rational protein design yields a CD20 CAR with superior antitumor efficacy compared to CD19 CAR.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0504
Abstract: Chimeric antigen receptors (CARs) are fusion proteins whose functional domains are often connected in a plug-and-play manner to generate multiple CAR variants. However, CARs with highly similar sequences can exhibit dramatic differences in function. Thus,… read more here.
Keywords: car; antitumor efficacy; cd20 car; cd19 car ... See more keywords
Optimization of Culture Conditions for the Generation of Canine CD20-CAR-T Cells for Adoptive Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "In Vivo"
DOI: 10.21873/invivo.12763
Abstract: Background/Aim: Chimeric antigen receptor (CAR) T cell therapy targeting CD20 has the potential to become a promising novel treatment for canine B cell lymphoid malignancy. However, the optimal approach for producing potent CAR-T cells with… read more here.
Keywords: adoptive immunotherapy; culture conditions; cd20 car; cells adoptive ... See more keywords