CD200 included in a 4‐marker modified Matutes score provides optimal sensitivity and specificity for the diagnosis of chronic lymphocytic leukaemia
Sign Up to like & getrecommendations! Published in 2018 at "Hematological Oncology"
DOI: 10.1002/hon.2510
Abstract: CD200, a transmembrane type Ia glycoprotein belonging to the immunoglobulin superfamily, has been shown to have a differential expression in B‐cell neoplasms. Here, we retrospectively assessed the diagnostic relevance of CD200 on 427 patients with… read more here.
Keywords: sensitivity specificity; cd200; matutes score; diagnosis ... See more keywords
Over-expression of CD200 predicts poor prognosis in MDS.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2017.01.021
Abstract: BACKGROUND We studied the expression of CD200 in a series of 101 patients with diagnosis of myelodysplastic syndrome (MDS), to evaluate its impact on outcome and its possible association with other known prognostic factors. MATERIAL/METHODS… read more here.
Keywords: predicts poor; cd200; expression; mds ... See more keywords
Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1426517
Abstract: ABSTRACT Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that responds to PD-1/PD-L1 immune checkpoint inhibitors. CD200 is another checkpoint modulator whose receptor is found on tumor-promoting myeloid cells, including M2 macrophages.… read more here.
Keywords: mcc; cell carcinoma; regulatory cells; immunosuppressive macrophages ... See more keywords
Use of an anti‐CD200‐blocking antibody improves immune responses to AML in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17125
Abstract: Treatment of relapsed/resistant acute myeloid leukaemia (AML) remains a significant area of unmet patient need, the outlook for most patients remaining extremely poor. A promising approach is to augment the anti‐tumour immune response in these… read more here.
Keywords: vitro vivo; anti cd200; antibody; immune responses ... See more keywords
CD200 Is a Stem Cell-Specific Immunosuppressive Target in AML
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DOI: 10.1182/blood-2018-99-114818
Abstract: Acute myeloid leukemia (AML) stem cells (LSC) are an extremely rare fraction of the overall disease (likely read more here.
Keywords: equity ownership; stem cell; cd200; aml ... See more keywords
Overexpression of CD200 Is a Stem Cell-Specific Mechanism of Immune Escape in AML
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood-2020-139434
Abstract: Background: Acute myeloid leukemia (AML) stem cells (LSC), the likely source of relapsed disease, are capable of surviving current standard chemotherapy. Therefore, novel therapeutic approaches specifically engineered to eradicate LSCs are critical for curing AML.… read more here.
Keywords: aml; cell; cd200; research funding ... See more keywords
The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0210796
Abstract: Tumor-infiltrating immune cells can impact tumor growth and progression. The inhibitory CD200 receptor (CD200R) suppresses the activation of myeloid cells and lack of this pathway results in a reduction of tumor growth, conversely a tumorigenic… read more here.
Keywords: agonistic cd200r; effect; cd200; cd200r ... See more keywords
Cancel cancer: The immunotherapeutic potential of CD200/CD200R blockade
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1088038
Abstract: Immune checkpoint molecules function to inhibit and regulate immune response pathways to prevent hyperactive immune activity from damaging healthy tissues. In cancer patients, targeting these key molecules may serve as a valuable therapeutic mechanism to… read more here.
Keywords: cd200; cd200 cd200r; cd200r; cd200r blockade ... See more keywords
Insights into the Potential Impact of Quetiapine on the Microglial Trajectory and Inflammatory Response in Organotypic Cortical Cultures Derived from Rat Offspring
Sign Up to like & getrecommendations! Published in 2023 at "Biomedicines"
DOI: 10.3390/biomedicines11051405
Abstract: Atypical antipsychotics currently constitute the first-line medication for schizophrenia, with quetiapine being one of the most commonly prescribed representatives of the group. Along with its specific affinity for multiple receptors, this compound exerts other biological… read more here.
Keywords: impact quetiapine; mia occs; cortical cultures; organotypic cortical ... See more keywords
Treatment Combining CD200 Immune Checkpoint Inhibitor and Tumor-Lysate Vaccination after Surgery for Pet Dogs with High-Grade Glioma
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11020137
Abstract: Recent advances in immunotherapy have included inhibition of immune checkpoint proteins in the tumor microenvironment and tumor lysate-based vaccination strategies. We combined these approaches in pet dogs with high-grade glioma. Administration of a synthetic peptide… read more here.
Keywords: immune checkpoint; tumor lysate; cd200;
CD200 Induces Epithelial-to-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma via β-Catenin-Mediated Nuclear Translocation
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11101583
Abstract: The membrane glycoprotein CD200 binds to its receptor CD200R1 and induces tolerance, mainly in cells of the myeloid lineage; however, information regarding its role in solid tumors is limited. Here, we investigated whether CD200 expression,… read more here.
Keywords: cell carcinoma; squamous cell; cd200; cell ... See more keywords