CD200R Is Involved in the Anti-inflammatory Effect of Dexmedetomidine in Lipopolysaccharide-Stimulated Microglia
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01244-7
Abstract: Dexmedetomidine has been confirmed to have anti-inflammatory effect in numerous diseases. However, the detailed mechanism is still unknown. We explore the hypothesis that CD200R is related to the anti-inflammatory effect of dexmedetomidine. Primary microglia were… read more here.
Keywords: anti inflammatory; effect dexmedetomidine; inflammatory effect; effect ... See more keywords
CD200R deletion promotes a neutrophil niche for Francisella tularensis and increases infectious burden and mortality
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DOI: 10.1038/s41467-019-10156-6
Abstract: Pulmonary immune control is crucial for protection against pathogens. Here we identify a pathway that promotes host responses during pulmonary bacterial infection; the expression of CD200 receptor (CD200R), which is known to dampen pulmonary immune… read more here.
Keywords: neutrophil niche; francisella tularensis; tularensis; cd200r ... See more keywords
CD200-CD200R imbalance correlates with microglia and pro-inflammatory activation in rat spinal cords exposed to amniotic fluid in retinoic acid-induced spina bifida
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-28829-5
Abstract: Spina bifida aperta is a congenital malformation characterized by the failure of neural tube closure resulting in an unprotected fetal spinal cord. The spinal cord then undergoes progressive damage, likely due to chemical and mechanical… read more here.
Keywords: activation; cd200r; retinoic acid; spinal cords ... See more keywords
A CD200R-CD28 fusion protein appropriates an inhibitory signal to enhance T-cell function and therapy of murine leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2017-04-777052
Abstract: Acute myeloid leukemia (AML), the most common adult acute leukemia in the United States, has the poorest survival rate, with 26% of patients surviving 5 years. Adoptive immunotherapy with T cells genetically modified to recognize… read more here.
Keywords: cd200r cd28; cell; cd200r; function ... See more keywords
The pro-tumor effect of CD200 expression is not mimicked by agonistic CD200R antibodies
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0210796
Abstract: Tumor-infiltrating immune cells can impact tumor growth and progression. The inhibitory CD200 receptor (CD200R) suppresses the activation of myeloid cells and lack of this pathway results in a reduction of tumor growth, conversely a tumorigenic… read more here.
Keywords: agonistic cd200r; effect; cd200; cd200r ... See more keywords
CD200-CD200R Interaction: An Important Regulator After Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2019.00840
Abstract: The high mortality and morbidity rate of stroke is a chronic problem that plagues human society. The activation of microglia is one of the principal reasons why neuroinflammation induces cerebral dysfunction. Because of their vital… read more here.
Keywords: interaction important; cd200r interaction; important regulator; cd200r ... See more keywords
Cancel cancer: The immunotherapeutic potential of CD200/CD200R blockade
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1088038
Abstract: Immune checkpoint molecules function to inhibit and regulate immune response pathways to prevent hyperactive immune activity from damaging healthy tissues. In cancer patients, targeting these key molecules may serve as a valuable therapeutic mechanism to… read more here.
Keywords: cd200; cd200 cd200r; cd200r; cd200r blockade ... See more keywords