Abstract 3763: UCART22: allogenic adoptive immunotherapy of leukemia by targeting CD22 with CAR T-cells
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DOI: 10.1158/1538-7445.am2017-3763
Abstract: Adoptive immunotherapy using autologous T-cells endowed with chimeric antigen receptors (CARs) has given rise to long-term durable remissions and remarkable objective response rates in patients with refractory leukemia, raising hopes that a wider application of… read more here.
Keywords: adoptive immunotherapy; cd22; targeting cd22; cd22 car ... See more keywords
Preclinical Evaluation of an Allogeneic CD22 CAR-NK to Target B-Cell Hematologic Malignancies
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DOI: 10.1182/blood-2024-198589
Abstract: Chimeric antigen receptor (CAR) immunotherapy targeting CD19 has shown remarkable responses and sustained remission in clinical trials for B cell malignancies. However, 30%-60% of patients relapse due to poor CAR-T persistence or CD19 antigen escape,… read more here.
Keywords: car; cell; tumor; car cells ... See more keywords
Safe and Effective Combination of Donor-Derived, Allogeneic CD19/CD22-CAR T Cells with Myeloablative Graft-Engineered Allo-HCT for High-Risk B-ALL
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DOI: 10.1182/blood-2024-211959
Abstract: Background: High-risk B-cell acute lymphoblastic leukemia (B-ALL) remains incurable for many patients despite treatment with autologous CAR T cells or allogeneic hematopoietic cell transplant (allo-HCT). We previously demonstrated that CAR T cells can be safely… read more here.
Keywords: cd19 cd22; cd22 car; car; car cells ... See more keywords
CD4/CD8 T-Cell Selection Enhances CD22 CAR-T Cell Transduction and in-Vivo CAR-T Expansion: Updated Results on Phase I Anti-CD22 CAR Dose Expansion Cohort
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DOI: 10.1182/blood.v130.suppl_1.809.809
Abstract: Background: We previously demonstrated that non-T cells in apheresis products collected from patients with cancer, particularly in those with circulating leukemic cells or low CD3 counts, can substantially affect T cell expansion and transduction and,… read more here.
Keywords: cd4 cd8; expansion; tcs; cd22 car ... See more keywords