Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.09.006
Abstract: CD8+ T cells within the tumor microenvironment (TME) are exposed to various signals that ultimately determine functional outcomes. Here, we examined the role of the co-activating receptor CD226 (DNAM-1) in CD8+ T cell function. The absence of… read more here.
Keywords: cd8 cell; tumor; efficacy; cd226 ... See more keywords
Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome
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DOI: 10.1038/s41598-021-81260-1
Abstract: This study was conducted to investigate the impact of genetic variants of immune checkpoint genes on the treatment outcome in small cell lung cancer (SCLC). In the present study, 261 platinum doublet-treated SCLC patients were… read more here.
Keywords: immune checkpoint; cd155; cell lung; cd226 ... See more keywords
TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004711
Abstract: Recent advances in understanding the roles of immune checkpoints in allowing tumors to circumvent the immune system have led to successful therapeutic strategies that have fundamentally changed oncology practice. Thus far, immunotherapies against only two… read more here.
Keywords: cd226; immune checkpoint; checkpoint; receptor ... See more keywords
CD226 Deficiency Alleviates Murine Allergic Rhinitis by Suppressing Group 2 Innate Lymphoid Cell Responses
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DOI: 10.1155/2022/1756395
Abstract: Allergic rhinitis (AR) is an immunoglobulin E-mediated type 2 inflammation of the nasal mucosa that is mainly driven by type 2 helper T cells (Th2) and type 2 innate lymphoid cells (ILC2s). CD226 is a… read more here.
Keywords: cell; nasal; cd226; cd226 deficiency ... See more keywords
Abstract 3477: Maximizing the outcome of CD226 stimulation through targeting beyond TIGIT signaling with combination and multi-specific approaches for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3477
Abstract: The CD226 (DNAM-1) axis has emerged as an important immune-modulatory pathway that regulates T cell and NK cell effector functions in the solid tumor microenvironment. Three inhibitory receptors, TIGIT, CD96, and PVRIG, inhibit the activating… read more here.
Keywords: multi specific; tigit; maximizing outcome; tumor ... See more keywords
CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.02180
Abstract: The costimulatory molecule CD226 is highly expressed on effector/memory T cells and natural killer cells. Costimulatory signals received by T cells can impact both central and peripheral tolerance mechanisms. Genetic polymorphisms in CD226 have been… read more here.
Keywords: cd226 mice; type diabetes; cell activation; cell ... See more keywords
Costimulatory CD226 Signaling Regulates Proliferation of Memory-like NK Cells in Healthy Individuals with Latent Mycobacterium tuberculosis Infection
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232112838
Abstract: It is now widely accepted that NK cells can acquire memory, and this makes them more effective to protect against some pathogens. Prior reports indicate memory-like NK cells (mlNKs) in murine model of Mycobacterium tuberculosis… read more here.
Keywords: memory like; cd226 signaling; ltbi people; mlnks ltbi ... See more keywords
Decrease in CD226 expression on CD4+ T cells in patients with endometriosis.
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience trends"
DOI: 10.5582/bst.2022.01501
Abstract: Endometriosis is a chronic inflammatory disease. The immune-checkpoint molecules CD226 and TIGIT play an important role in regulating T cells' function. However, little is known about the proportion and function of CD226 and TIGIT on… read more here.
Keywords: cd4; cd4 cells; patients endometriosis; cells patients ... See more keywords