LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "cd248" as a keyword



Bioactive siRNA‐Based Liposomes Promoted Tendon‐Bone Healing in Osteoporotic Mice by Recovering the Stemness of CD248+ TSPCs

Sign Up to like & get
recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202509883

Abstract: Osteoporosis significantly impairs tendon‐bone healing, increasing the risk of rotator cuff tears and postoperative retearing. Tendon stem/progenitor cells (TSPCs) are vital for tendon repair, with their stemness crucial to healing outcomes. This study investigated the… read more here.

Keywords: healing osteoporotic; cd248; bone healing; tendon ... See more keywords

Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation

Sign Up to like & get
recommendations! Published in 2019 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2019.05.057

Abstract: Background A positive energy balance promotes white adipose tissue (WAT) expansion which is characterized by activation of a repertoire of events including hypoxia, inflammation and extracellular matrix remodelling. The transmembrane glycoprotein CD248 has been implicated… read more here.

Keywords: cd248; inflammation; white adipose; adipose tissue ... See more keywords
Photo from wikipedia

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface

Sign Up to like & get
recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2017.214

Abstract: The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a… read more here.

Keywords: clec14a cd93; cd248; family; mmrn2 ... See more keywords
Photo from wikipedia

Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis

Sign Up to like & get
recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-73194-x

Abstract: The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney… read more here.

Keywords: cd248 mice; fibrosis; cd248; tissue fibrosis ... See more keywords

CD248‐expressing cancer‐associated fibroblasts induce non‐small cell lung cancer metastasis via Hippo pathway‐mediated extracellular matrix stiffness

Sign Up to like & get
recommendations! Published in 2024 at "Journal of Cellular and Molecular Medicine"

DOI: 10.1111/jcmm.70025

Abstract: Metastasis is a crucial stage in tumour progression, and cancer‐associated fibroblasts (CAFs) support metastasis through their participation in extracellular matrix (ECM) stiffness. CD248 is a possible biomarker for non‐small cell lung cancer (NSCLC)‐derived CAFs, but… read more here.

Keywords: cancer; matrix; lung; cd248 ... See more keywords

Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome

Sign Up to like & get
recommendations! Published in 2023 at "PLOS ONE"

DOI: 10.1371/journal.pone.0284012

Abstract: Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic… read more here.

Keywords: cd248 mice; adipose tissue; sex specific; mice ... See more keywords

Prognostic Value of Vascular-Expressed PSMA and CD248 in Urothelial Carcinoma of the Bladder

Sign Up to like & get
recommendations! Published in 2021 at "Frontiers in Oncology"

DOI: 10.3389/fonc.2021.771036

Abstract: Background Urothelial carcinoma of the bladder (UCB) is a common cancer of the urinary system. Despite substantial improvements in available treatment options, the survival outcome of patients with advanced UCB is unsatisfactory. Therefore, it is… read more here.

Keywords: expression; carcinoma bladder; urothelial carcinoma; cd248 ... See more keywords

Inflammatory Mesenchymal Stem Cells Express Abundant Membrane-Bound and Soluble Forms of C-Type Lectin-like CD248

Sign Up to like & get
recommendations! Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24119546

Abstract: CD248 (endosialin) belongs to a glycoprotein family that also includes thrombomodulin (CD141), CLEC14A, and CD93 (AA4) stem cell markers. We analyzed the regulated expression of CD248 in vitro using skin (HFFF) and synovial (FLS) mesenchymal… read more here.

Keywords: bound soluble; mesenchymal stem; stem; membrane bound ... See more keywords