Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis
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DOI: 10.1038/s41598-020-73194-x
Abstract: The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney… read more here.
Keywords: cd248 mice; fibrosis; cd248; tissue fibrosis ... See more keywords
Sex-specific effects of CD248 on metabolism and the adipose tissue lipidome
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DOI: 10.1371/journal.pone.0284012
Abstract: Cd248 has recently been associated with adipose tissue physiology, demonstrated by reduced weight gain in high fat diet-fed mice with genetic deletion of Cd248 relative to controls. Here we set out to determine the metabolic… read more here.
Keywords: cd248 mice; adipose tissue; sex specific; mice ... See more keywords