Expansion of GARP-Expressing CD4+CD25-FoxP3+ T Cells and SATB1 Association with Activation and Coagulation in Immune Compromised HIV-1-Infected Individuals in South Africa.
Sign Up to like & getrecommendations! Published in 2021 at "Virologica Sinica"
DOI: 10.1007/s12250-021-00386-8
Abstract: Although antiretroviral treatment lowers the burden of human immunodeficiency virus (HIV)-related disease, it does not always result in immunological recovery. This manifests as persistent chronic inflammation, immune activation or exhaustion that can promote the onset… read more here.
Keywords: coagulation; cd4 cd25; hiv; cd25 ... See more keywords
Low expressions of PD-L1 and CTLA-4 by induced CD4+CD25+ Foxp3+ Tregs in patients with SLE and their correlation with the disease activity.
Sign Up to like & getrecommendations! Published in 2020 at "Cytokine"
DOI: 10.1016/j.cyto.2020.155119
Abstract: BACKGROUND The induction of CD4+CD25+Foxp3+ Treg from CD4+CD25- T cells is deficient in the patients with systemic lupus erythematosus (SLE). Whether the induced CD4+CD25+Foxp3+ Tregs possess defective function remains unclear. The purpose of the present… read more here.
Keywords: cd4 cd25; induced cd4; cd25; cd25 foxp3 ... See more keywords
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials
Sign Up to like & getrecommendations! Published in 2021 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2021.103345
Abstract: Background near-infrared photoimmunotherapy (NIR-PIT) is a cancer treatment that uses antibody-photoabsorber (IRDye700DX, IR700) conjugates (APCs) which bind to target cells and are photoactivated by NIR light inducing rapid necrotic cell death. NIR-PIT targeting human epidermal… read more here.
Keywords: pit; nir pit; hegfr; cd25 ... See more keywords
Design, isolation and evaluation of the binding efficiency of a DNA aptamer against interleukin 2 receptor alpha, in vitro
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.10.011
Abstract: Abstract High levels of CD25, as part of the IL‐2 receptor, are expressed on the surface of the activated T lymphocytes and regulatory T cells, indicating that the soluble CD25 (sCD25) could be a clinically… read more here.
Keywords: high affinity; apt51; design isolation; cd25 ... See more keywords
Low CD25 on autoreactive Tregs impairs tolerance via low dose IL-2 and antigen delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.01.005
Abstract: Dendritic cell (DC)-mediated T cell tolerance deficiencies contribute to the pathogenesis of autoimmune diseases such as type 1 diabetes. Delivering self-antigen to dendritic-cell inhibitory receptor-2 (DCIR2)+ DCs can delay but not completely block diabetes development… read more here.
Keywords: tregs; islet; tolerance via; cd25 ... See more keywords
CD4+CD25+ Tregs as dependent factor in the course of bleomycin-induced pulmonary fibrosis in mice.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111700
Abstract: The immune system is felt to play an essential role in pulmonary fibrosis (PF). CD4+CD25+ regulatory T cells (Tregs) are crucial in maintaining immune tolerance and immune homeostasis, but their role in the pathogenesis of… read more here.
Keywords: fibrosis; cd4 cd25; cd25 tregs; course ... See more keywords
Multiple sclerosis patients have reduced resting and increased activated CD4+CD25+FOXP3+T regulatory cells
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88448-5
Abstract: Resting and activated subpopulations of CD4+CD25+CD127loT regulatory cells (Treg) and CD4+CD25+CD127+ effector T cells in MS patients and in healthy individuals were compared. Peripheral blood mononuclear cells isolated using Ficoll Hypaque were stained with monoclonal… read more here.
Keywords: cd4 cd25; cd25; treg; population ... See more keywords
Decreased regulatory function of CD4+CD25+CD45RA+ T cells and impaired IL‐2 signalling pathway in patients with type 2 diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12711
Abstract: In this study, the frequency and function of CD4+CD25+CD45RA+ regulatory T cells (Treg) and intracellular IL‐2 signalling molecules in patients with type 2 diabetes mellitus (T2DM) were investigated. Tregs and responder T cells (Tresp, CD4+CD25−… read more here.
Keywords: cd4 cd25; cd25; cd25 cd45ra; function cd4 ... See more keywords
Prognostic significance of CD25 expression in dogs with a noninvasive diagnosis of B-cell lymphoma treated with CHOP chemotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12857
Abstract: Prior studies have identified high CD25 expression in canine diffuse large B-cell lymphoma as a negative prognostic indicator. The objective of this retrospective study was to evaluate CD25 expression as a prognostic indicator in dogs… read more here.
Keywords: cell lymphoma; cd25; chop chemotherapy; cd25 expression ... See more keywords
Abstract 1801: STK-012, an a/b-selective IL-2 activates tumor antigen specific CD25+ CD8 T cells to reject tumors without acute vascular toxicity
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1801
Abstract: High-dose Interleukin-2 (IL-2) monotherapy induces complete responses in cancer patients but its use is limited by acute vascular toxicities including capillary leak syndrome and severe hypotension 1,2. IL-2 activates lymphocytes and NK-cells through the intermediate-affinity… read more here.
Keywords: antigen; acute vascular; cd25; antigen specific ... See more keywords
Abstract 3239: Selective depletion of regulatory T cells by ALD2510, a novel IL-2-sparing anti-CD25 antibody, synergizes with PD-1 blockade in breast and gynecologic cancers
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3239
Abstract: Background: PD-1 blockade (αPD-1) has shown limited efficacy in breast & gynecologic cancers. In other types of solid tumor, regulatory T cells (Tregs) harbouring markers of highly suppressive effector Tregs (eTregs) correlates with poor responses… read more here.
Keywords: breast gynecologic; regulatory cells; gynecologic cancers; cd25 ... See more keywords