Combination of anti‐CD25 antibody and poly I:C treatment in pregnant NOD mice may be used as ‘pregnancy‐related’ type 1 diabetes model
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DOI: 10.1111/jdi.13829
Abstract: Some women develop type 1 diabetes during pregnancy or immediately after delivery. However, the underlying pathophysiology remains largely unknown, probably because of the lack of a suitable animal model. In this study, we administered pregnant NOD… read more here.
Keywords: pregnant nod; nod mice; type diabetes; cd25 antibody ... See more keywords
Abstract 710: Preclinical development of ALD2510, a Next-Gen Fc-enhanced, TREG-selective and IL-2-sparing anti-CD25 antibody for the treatment of solid tumors
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DOI: 10.1158/1538-7445.am2023-710
Abstract: Within the tumor microenvironment (TME), TREGS have been associated with worse prognosis and/or resistance to checkpoint inhibitor (CPI) therapy in various cancer diseases, making these cells a promising target for the development of new immunotherapies.… read more here.
Keywords: development; anti cd25; preclinical development; cd25 antibody ... See more keywords
Regulatory T Cell Depletion Using a CRISPR Fc-Optimized CD25 Antibody
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DOI: 10.3390/ijms23158707
Abstract: Regulatory T cells (Tregs) are major drivers behind immunosuppressive mechanisms and present a major hurdle for cancer therapy. Tregs are characterized by a high expression of CD25, which is a potentially valuable target for Treg… read more here.
Keywords: cell; cd25; depletion; cd25 antibody ... See more keywords