Humanized anti-CD25 monoclonal antibody for previously treated hemophagocytic lymphohistiocytosis in adults: A prospective, open-label clinical trial
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DOI: 10.1182/blood-2025-1226
Abstract: Hemophagocytic lymphohistiocytosis (HLH) is a rare syndrome characterized by immune dysregulation and hyperinflammation. It is associated with low incidence and high mortality. Therapeutic options for HLH are limited, underscoring the necessity for novel treatment strategies.… read more here.
Keywords: treatment; cd25 mab; infection; anti cd25 ... See more keywords
First-in-human phase I trial combining radiopharmaceutical therapy (RPT) using a 90y-anti-CD25 monoclonal antibody (Mab) with total marrow and lymphoid irradiation (TMLI) in relapsed or refractory (R/R) acute leukemia
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DOI: 10.1182/blood-2025-508
Abstract: Purpose: Patients with R/R acute leukemia who undergo allogeneic hematopoietic cell transplantation (alloHCT) have a dismal prognosis. A phase 2 randomized trial in AML demonstrated that a higher total body irradiation (TBI) dose decreased relapse… read more here.
Keywords: marrow; trial; cd25 mab; anti cd25 ... See more keywords