Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model
Sign Up to like & getrecommendations! Published in 2019 at "Inflammation Research"
DOI: 10.1007/s00011-019-01236-w
Abstract: BackgroundPseudomonas aeruginosa (PA) is the most important opportunistic pathogen in causing nosocomial infections and, furthermore, poses a permanent threat for severe chronic infections in patients with cystic fibrosis or COPD. The transmembrane protein CD26 with… read more here.
Keywords: dpp4; lung infection; cd26; cd26 dpp4 ... See more keywords
Targeting CD26/DPP4 in organ fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "British journal of pharmacology"
DOI: 10.1111/bph.15967
Abstract: CD26/DPP4 is an exopeptidase that is expressed as a transmembrane protein in many organs but also present in a circulating soluble form. Beyond its enzymatic and co-stimulatory activity, CD26/DPP4 is involved in the pathogenesis of… read more here.
Keywords: organ fibrosis; targeting cd26; dpp4; cd26 dpp4 ... See more keywords
Differential severity of LPS-induced lung injury in CD26/DPP4 positive and deficient F344 rats.
Sign Up to like & getrecommendations! Published in 2019 at "Histology and histopathology"
DOI: 10.14670/hh-18-117
Abstract: BACKGROUND Lipopolysaccharide (LPS) induced inflammation often leads to lung injury, in which pulmonary recruitment of neutrophils plays a pivotal role. Inflammatory processes are influenced by CD26/DPP4, highly expressed in lungs. Asthma induced CD26/DPP4 deficient (CD26/DPP4⁻)… read more here.
Keywords: dpp4; lps induced; cd26 dpp4; lung injury ... See more keywords
Functional roles of CD26/DPP4 in bleomycin‐induced pulmonary fibrosis
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DOI: 10.14814/phy2.15645
Abstract: The pathogenesis of pulmonary fibrosis involves complex interplay between cell types and signaling pathways. Recurrent alveolar epithelial injury can occur during pulmonary inflammation, causing dysregulation of epithelial repair. Dysregulated repair interacts with mesenchymal, inflammatory, and… read more here.
Keywords: pulmonary fibrosis; bleomycin; induced pulmonary; fibrosis ... See more keywords
The Serine Protease CD26/DPP4 in Non-Transformed and Malignant T Cells
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DOI: 10.3390/cancers13235947
Abstract: Simple Summary The transmembrane serine protease CD26/Dipeptidylpeptidase 4 modulates T-cell activation, proliferation, and effector function. Due to their remarkable tumoricidal properties CD26-positive T cells are considered promising candidates for T cell-based immunotherapies while in cutaneous… read more here.
Keywords: cd26 dpp4; cd26; cell; serine protease ... See more keywords
CD26/DPP4 as a Therapeutic Target in Nonalcoholic Steatohepatitis Associated Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14020454
Abstract: Simple Summary CD26/DPP4 has been reported to attenuate anticancer immunity via chemokine cleavage and to promote insulin resistance and inflammation in the liver and/or adipose tissue via dysregulation of macrophage M1/M2 polarization. These results suggest… read more here.
Keywords: hepatocellular carcinoma; dpp4; nonalcoholic steatohepatitis; associated hepatocellular ... See more keywords