Agonistic CD27 antibody potency is determined by epitope-dependent receptor clustering augmented through Fc-engineering
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03182-6
Abstract: Agonistic CD27 monoclonal antibodies (mAb) have demonstrated impressive anti-tumour efficacy in multiple preclinical models but modest clinical responses. This might reflect current reagents delivering suboptimal CD27 agonism. Here, using a novel panel of CD27 mAb… read more here.
Keywords: receptor clustering; engineering; agonistic cd27; cd27 ... See more keywords
Soluble CD27 as a predictive biomarker for intra‐tumoral CD70/CD27 interaction in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Science"
DOI: 10.1111/cas.16079
Abstract: In CD70‐expressing tumors, the interaction of CD70 on tumor cells with its lymphocyte receptor, CD27, is thought to play a role in immunosuppression in the tumor microenvironment and elevated serum levels of soluble CD27 (sCD27).… read more here.
Keywords: cd70 cd27; cd70; tumor; cd27 interaction ... See more keywords
Abstract 4690: Hexavalent CD27 agonists show single agent anti-tumor activity and enhanced memory formation in mouse syngeneic tumor models
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-4690
Abstract: Tumor necrosis factor receptor superfamily (TNFRSF) proteins are widely expressed by immune and tumor cells highlighting their importance in multiple locations and phases of the anti-tumor immune response. Apogenix has developed a proprietary technology platform… read more here.
Keywords: hera cd27l; cd27; hera; anti tumor ... See more keywords
CD70 reverse signaling enhances NK cell function and immunosurveillance in CD27-expressing B-cell malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood-2016-12-756585
Abstract: The interaction of the tumor necrosis factor receptor (TNFR) CD27 with its ligand CD70 is an emerging target to treat cancer. CD27 signaling provides costimulatory signals to cytotoxic T cells but also increases the frequency… read more here.
Keywords: cd27; cd70 reverse; function; cell ... See more keywords
Novel Natural Ligand Chimeric Antigen Receptors (CARs) Targeting CD70 with a Redesigned CD27 Binding Interface Provide Enhanced Potency Against Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-204895
Abstract: Introduction: Chimeric antigen receptor (CAR) T cell therapies have brought tremendous progress in the treatment of B lymphoid and plasma cell malignancies, but development for acute myeloid leukemia (AML) has been difficult. CD70 is an… read more here.
Keywords: binding interface; car; leukemia; cd8 cd27 ... See more keywords
Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2019001079
Abstract: CD27, a costimulatory molecule on T cells, induces intracellular signals mediating cellular activation, proliferation, effector function, and cell survival on binding to its ligand, CD70. Varlilumab, a novel, first-in-class, agonist immunoglobulin G1 anti-CD27 antibody, mediates… read more here.
Keywords: cd27; hematologic malignancies; novel first; varlilumab novel ... See more keywords
Assessing the causal relationship between 731 immunophenotypes and the risk of lung cancer: a bidirectional mendelian randomization study
Sign Up to like & getrecommendations! Published in 2024 at "BMC Cancer"
DOI: 10.1186/s12885-024-12014-1
Abstract: Previous studies have observed a link between immunophenotypes and lung cancer, both of which are closely associated with genetic factors. However, the causal relationship between them remains unclear. Bidirectional Mendelian randomization (MR) was performed on… read more here.
Keywords: cancer; lung cancer; risk; causal relationship ... See more keywords
Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-024-03077-9
Abstract: Objective Soluble CD27 is a promising cerebrospinal fluid inflammatory biomarker in multiple sclerosis. In this study, we investigate relevant immune and neuro-pathological features of soluble CD27 in multiple sclerosis. Methods Protein levels of soluble CD27… read more here.
Keywords: multiple sclerosis; soluble cd27; cell; biomarker ... See more keywords
A phase 1 dose-escalation study of a PD-L1xCD27 bispecific antibody CDX-527 in patients with advanced malignancies.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.2585
Abstract: 2585 Background: CDX-527 is a bispecific antibody (BsAb) targeting PD-L1 and CD27 that is designed to block immune checkpoint PD-L1/PD-1 interactions while providing immune costimulation through CD27 signaling. CD27 is a key immunostimulatory molecule that… read more here.
Keywords: cd27; activity; cdx 527; bispecific antibody ... See more keywords
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0180691
Abstract: Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+CD27-CD28- regulatory T cells… read more here.
Keywords: cd27 cd28; cmv seropositive; cd27; cd4 cd27 ... See more keywords
CD27 as a Diagnostic Biomarker and Its Role in Immune Heterogeneity and Predicting Clinical Drug Responses in Hashimoto’s Thyroiditis
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DOI: 10.2147/pgpm.s487091
Abstract: Objective To identify key genes and potential molecular mechanisms associated with Hashimoto’s thyroiditis (HT) to provide new insights for the development of diagnostic and therapeutic targets for this disease. Methods Differential expression analysis and weighted… read more here.
Keywords: predicting clinical; hashimoto thyroiditis; analysis; expression ... See more keywords